{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T21:03:58Z","timestamp":1782421438277,"version":"3.54.5"},"reference-count":72,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014370","name":"Simons Foundation Autism Research Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      16p11.2 copy\u2010number variation (CNV) is implicated in neurodevelopmental disorders, with the duplication and deletion associated with autism spectrum disorder (ASD) and the duplication associated with schizophrenia (SCZ). The 16p11.2 CNV may therefore provide insight into the relationship between ASD and SCZ, distinct disorders that co\u2010occur at an elevated rate, and are difficult to distinguish from each other and from common co\u2010occurring diagnoses such as obsessive compulsive disorder (OCD), itself a potential risk factor for SCZ. As psychotic symptoms are core to SCZ but distinct from ASD, we sought to examine their predictors in a population (\n                      <jats:italic>n<\/jats:italic>\n                      =\u2009546) of 16p11.2 CNV carriers and their noncarrier siblings recruited by the Simons Variation in Individuals Project. We hypothesized that psychotic symptoms would be most common in duplication carriers followed by deletion carriers and noncarriers, that an ASD diagnosis would predict psychotic symptoms among CNV carriers, and that OCD symptoms would predict psychotic symptoms among all participants. Using data collected across multiple measures, we identified 19 participants with psychotic symptoms. Logistic regression models adjusting for biological sex, age, and IQ found that 16p11.2 duplication and ASD diagnosis predicted psychotic symptom presence. Our findings suggest that the association between 16p11.2 duplication and psychotic symptoms is independent of ASD diagnosis and that ASD diagnosis and psychotic symptoms may be associated in 16p11.2 CNV carriers.\n                      <jats:bold>\n                        <jats:italic>Autism Res<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>2020, 13: 187\u2013198<\/jats:italic>\n                      . \u00a9 2019 International Society for Autism Research, Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay Summary<\/jats:title>\n                    <jats:p>Either deletion or duplication at chromosome 16p11.2 raises the risk of autism spectrum disorder, and duplication, but not deletion, has been reported in schizophrenia (SCZ). In a sample of 16p11.2 deletion and duplication carriers, we found that having the duplication or having an autism diagnosis may increase the risk of psychosis, a key feature of SCZ.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/aur.2232","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T07:41:13Z","timestamp":1573717273000},"page":"187-198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Psychotic symptoms in 16p11.2 copy\u2010number variant carriers"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5973-9940","authenticated-orcid":false,"given":"Amandeep","family":"Jutla","sequence":"first","affiliation":[{"name":"Department of Psychiatry Columbia University  New York New York"},{"name":"New York State Psychiatric Institute  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Blake","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Columbia University  New York New York"},{"name":"New York State Psychiatric Institute  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LeeAnne","family":"Green Snyder","sequence":"additional","affiliation":[{"name":"Simons Foundation  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy K.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Department of Medicine Columbia University  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Veenstra\u2010VanderWeele","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Columbia University  New York New York"},{"name":"New York State Psychiatric Institute  New York New York"},{"name":"Center for Autism and the Developing Brain New York\u2010Presbyterian Hospital  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Manual for the ASEBA School\u2010Age Forms & Profiles","author":"Achenbach T. M.","year":"2001"},{"key":"e_1_2_8_3_1","volume-title":"Manual for the ASEBA Adult Forms & Profiles","author":"Achenbach T. M.","year":"2003"},{"key":"e_1_2_8_4_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1980"},{"key":"e_1_2_8_5_1","unstructured":"Bache S. M. &Wickham H. (2014).Magrittr: A forward\u2010pipe operator for R (Version 1.5).https:\/\/CRAN.R-project.org\/package=magrittr"},{"issue":"175","key":"e_1_2_8_6_1","first-page":"1","article-title":"A comparison of neuroimaging findings in childhood onset schizophrenia and autism spectrum disorder: A review of the literature","volume":"4","author":"Baribeau D. A.","year":"2013","journal-title":"Frontiers in Psychiatry"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2018.06.038"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0b013e3181e56ddd"},{"key":"e_1_2_8_9_1","unstructured":"Constantino J. N.(2005).Social Responsiveness Scale. Torrance CA: Western Psychological Services."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.12.014"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07458"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2001.3.2\/hcourvoisie"},{"key":"e_1_2_8_13_1","volume-title":"SCL\u201090\u2010R: Symptom Checklist\u201090\u2010R: Administration, Scoring, and Procedures Manual","author":"Derogatis L. R.","year":"1994"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:JADD.0000006005.31818.1c"},{"key":"e_1_2_8_15_1","volume-title":"Differential Ability Scales\u2010II","author":"Elliot C. D.","year":"2007"},{"key":"e_1_2_8_16_1","first-page":"767","volume-title":"Handbook of Clinical Neurology","author":"Fernandez T. V.","year":"2018"},{"key":"e_1_2_8_17_1","unstructured":"Fife D. (2019).Fifer: A collection of R functions for data manipulation data analysis and plotting (Version 1.1).https:\/\/github.com\/dustinfife\/fifer"},{"key":"e_1_2_8_18_1","unstructured":"Gelman A. Su Y.\u2010S. Yajima M. Hill J. Pittau M. G. Kerman J. \u2026Dorie V.(2018).Arm: Data analysis using regression and multilevel\/hierarchical models (Version 1.10\u20131).https:\/\/CRAN.R-project.org\/package=arm"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.09.025"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-008-0674-3"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2017.03.011"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf215"},{"key":"e_1_2_8_23_1","unstructured":"Henry L. &Wickham H. (2019).Purrr: Functional programming tools (Version 0.2.5)."},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rasd.2016.04.002"},{"key":"e_1_2_8_25_1","unstructured":"Hojsgaard S. Halekoh U. &Yan J.(2016).Geepack: Generalized estimating equation package (Version 1.2\u20101)."},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbu188"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-006-0299-3"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-012-1719-1"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-014-2080-3"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09552"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10578-017-0717-0"},{"key":"e_1_2_8_32_1","first-page":"217","article-title":"Autistic disturbances of affective contact","volume":"2","author":"Kanner L.","year":"1943","journal-title":"Nervous Child"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.118.545.381"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0957154X04044603"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.08.022"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1801490"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31129-2"},{"key":"e_1_2_8_38_1","volume-title":"Autism Diagnostic Observation Schedule, modules 1\u20134","author":"Lord C.","year":"2012"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717002367"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3725"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10862-010-9198-1"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.474"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-010-0892-1_7"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2014.04.022"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.1011"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.28"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0339-8"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-010-1015-x"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.110.084384"},{"key":"e_1_2_8_50_1","volume-title":"R: A Language and Environment for Statistical Computing (Version 3.5.1)","author":"R Core Team","year":"2018"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/CHI.0b013e31818b1c63"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.23"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.113.131052"},{"key":"e_1_2_8_54_1","unstructured":"Robinson D. Hayes A. Gomez M. Demeshev B. Menne D. Nutter B. \u2026Werner K. D.(2018). Broom: Convert statistical analysis objects into tidy tibbles (Version 0.5.0).https:\/\/CRAN.R-project.org\/package=broom"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01537622"},{"key":"e_1_2_8_56_1","volume-title":"Social communication questionnaire","author":"Rutter M.","year":"2003"},{"key":"e_1_2_8_57_1","volume-title":"Autism diagnostic interview\u2010Revised (vol. 29)","author":"Rutter M.","year":"2003"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200001000-00014"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-79948-3_1570"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.02.014"},{"key":"e_1_2_8_61_1","volume-title":"Vineland Adaptive Behavior Scales: Vineland\u2010II Survey Forms Manual","author":"Sparrow S. S.","year":"2005"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.157"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2013.10.033"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap8757"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2010.01609.x"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-016-0267-3"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwk052"},{"key":"e_1_2_8_68_1","volume-title":"Wechsler abbreviated scale of intelligence","author":"Wechsler D.","year":"1999"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa075974"},{"key":"e_1_2_8_70_1","unstructured":"Wickham H. Fran\u00e7ois R. Henry L. &M\u00fcller K. (2018). Dplyr: A grammar of data manipulation (Version 0.7.8).https:\/\/CRAN.R-project.org\/package=dplyr"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-004-0363-5"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3871"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1977"}],"container-title":["Autism Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aur.2232","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/aur.2232","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aur.2232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T10:04:16Z","timestamp":1694081056000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/aur.2232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,14]]},"references-count":72,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1002\/aur.2232"],"URL":"https:\/\/doi.org\/10.1002\/aur.2232","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/621250","asserted-by":"object"}]},"ISSN":["1939-3792","1939-3806"],"issn-type":[{"value":"1939-3792","type":"print"},{"value":"1939-3806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,14]]},"assertion":[{"value":"2019-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}