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We compared, using magnetic resonance imaging, the in vivo anatomy of the AH in 32 healthy individuals with Asperger syndrome (12\u201347 years) and 32 healthy controls who did not differ significantly in age or IQ. We measured bulk (gray + white matter) volume of the AH using manual tracing (MEASURE). We first compared the volume of AH between individuals with Asperger syndrome and controls and then investigated age\u2010related differences. We compared differences in anatomy before, and after, correcting for whole brain size. There was no significant between group differences in whole brain volume. However, individuals with Asperger syndrome had a significantly larger raw bulk volume of total (<jats:italic>P<\/jats:italic>&lt;0.01), right (<jats:italic>P<\/jats:italic>&lt;0.01), and left amygdala (<jats:italic>P<\/jats:italic>&lt;0.05); and when corrected for overall brain size, total (<jats:italic>P<\/jats:italic>&lt;0.05), and right amygdala (<jats:italic>P<\/jats:italic>&lt;0.01). There was a significant group difference in aging of left amygdala; controls, but not individuals with Asperger syndrome, had a significant age\u2010related increase in volume (<jats:italic>r<\/jats:italic> = 0.486, <jats:italic>P<\/jats:italic>&lt;0.01, and <jats:italic>r<\/jats:italic> = 0.007, <jats:italic>P<\/jats:italic> = 0.97, <jats:italic>z<\/jats:italic> = 1.995). There were no significant group differences in volume or age\u2010related effects in hippocampus. Individuals with Asperger syndrome have significant differences from controls in bulk volume and aging of the amygdala. <jats:bold><jats:italic>Autism Res<\/jats:italic><\/jats:bold> <jats:italic>2012,5:3\u201312<\/jats:italic>. \u00a9 2011 International Society for Autism Research, Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/aur.227","type":"journal-article","created":{"date-parts":[[2011,9,26]],"date-time":"2011-09-26T04:55:26Z","timestamp":1317012926000},"page":"3-12","source":"Crossref","is-referenced-by-count":45,"title":["Anatomy and aging of the amygdala and hippocampus in autism spectrum disorder: an in vivo magnetic resonance imaging study of Asperger syndrome"],"prefix":"10.1002","volume":"5","author":[{"given":"Clodagh 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