{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:37:18Z","timestamp":1773304638206,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010433","name":"Cooperative Research Centre for Living with Autism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010433","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001215","name":"La Trobe University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001215","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Recent evidence suggests the link between caregiver psychological distress and offspring social\u2010emotional difficulties may be accounted for by offspring temperament characteristics. However, existing studies have only focused on neurotypical children; thus, the current study sought to provide an initial examination of this process among children with varying levels of early autism features. Participants included 103 infants aged 9\u201316\u2009months (<jats:italic>M<\/jats:italic> = 12.39, SD = 1.97; 68% male) and their primary caregiver (96% mothers) referred to a larger study by community healthcare professionals. We utilized caregiver\u2010reported measures of psychological distress (Depression Anxiety Stress Scales), infant temperament (Infant Behavior Questionnaire\u2010Revised) and internalizing and externalizing symptoms (Infant\u2010Toddler Social and Emotional Assessment) and administered the Autism Observation Schedule for Infants (AOSI) at an assessment visit to quantify autism features. Infant negative affectivity was found to mediate positive concurrent relations between caregiver psychological distress and infant internalizing and externalizing symptoms, irrespective of the infants' AOSI score. While preliminary and cross\u2010sectional, these results replicate and extend previous findings suggesting that the pathway from caregiver psychological distress to negative affectivity to social\u2010emotional difficulties might also be apparent among infants with varying levels of autism features. More rigorous tests of causal effects await future longitudinal investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay Summary<\/jats:title><jats:p>Offspring of caregivers experiencing psychological distress (i.e., symptoms of depression, anxiety, and\/or stress) may themselves be at increased risk of poor mental health outcomes. Several previous studies conducted with neurotypical children suggest that this link from caregiver\u2010to\u2010child may be facilitated by children's temperament qualities. This study was a preliminary cross\u2010sectional exploration of these relationships in infants with features of autism. We found that infants' elevated negative emotions were involved in the relation between caregiver heightened psychological distress and children's mental health difficulties, consistent with neurotypical development. <jats:italic><jats:bold>Autism Res<\/jats:bold> 2020, 13: 1349\u20131357<\/jats:italic>. \u00a9 2020 International Society for Autism Research, Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/aur.2296","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T08:41:10Z","timestamp":1589186470000},"page":"1349-1357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Role of Negative Affectivity in Concurrent Relations Between Caregiver Psychological Distress and <scp>Social\u2010Emotional<\/scp> Difficulties in Infants With Early Signs of Autism"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9360-0851","authenticated-orcid":false,"given":"Lacey","family":"Chetcuti","sequence":"first","affiliation":[{"name":"School of Psychology and Public Health La Trobe University  Melbourne Victoria Australia"},{"name":"Cooperative Research Centre for Living with Autism (Autism CRC)  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7481-3923","authenticated-orcid":false,"given":"Mirko","family":"Uljarevi\u0107","sequence":"additional","affiliation":[{"name":"Stanford Autism Center, Department of Psychiatry and Behavioral Sciences, Child and Adolescent Psychiatry, School of Medicine Stanford University  Stanford California USA"},{"name":"Melbourne School of Psychological Sciences, Faculty of Medicine, Dentistry and Health Sciences The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3412-7910","authenticated-orcid":false,"given":"Kandice J.","family":"Varcin","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute University of Western Australia  Subiaco Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0545-0353","authenticated-orcid":false,"given":"Maryam","family":"Boutrus","sequence":"additional","affiliation":[{"name":"Cooperative Research Centre for Living with Autism (Autism CRC)  Brisbane Queensland Australia"},{"name":"Telethon Kids Institute University of Western Australia  Subiaco Western Australia Australia"},{"name":"School of Psychological Science University of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5353-786X","authenticated-orcid":false,"given":"Ming Wai","family":"Wan","sequence":"additional","affiliation":[{"name":"Division of Psychology and Mental Health, School of Health Sciences University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3339-2365","authenticated-orcid":false,"given":"Vicky","family":"Slonims","sequence":"additional","affiliation":[{"name":"Children's Neurosciences, Evelina London Children's Hospital, Institute of Psychiatry, Psychology &amp; Neuroscience Kings College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0143-181X","authenticated-orcid":false,"given":"Jonathan","family":"Green","sequence":"additional","affiliation":[{"name":"Division of Neuroscience &amp; Experimental Psychology, School of Biological Sciences University of Manchester  Manchester UK"},{"name":"Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust Greater Manchester Mental Health NHS Trust  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6391-6791","authenticated-orcid":false,"given":"Leonie","family":"Segal","sequence":"additional","affiliation":[{"name":"Australian Centre for Precision Health, School of Health Sciences University of South Australia  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7988-9951","authenticated-orcid":false,"given":"Teresa","family":"Iacono","sequence":"additional","affiliation":[{"name":"La Trobe Rural Health School  Bendigo Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8771-4027","authenticated-orcid":false,"given":"Cheryl","family":"Dissanayake","sequence":"additional","affiliation":[{"name":"Cooperative Research Centre for Living with Autism (Autism CRC)  Brisbane Queensland Australia"},{"name":"Olga Tennison Autism Research Centre, School of Psychology and Public Health La Trobe University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8722-1575","authenticated-orcid":false,"given":"Andrew J.O.","family":"Whitehouse","sequence":"additional","affiliation":[{"name":"Cooperative Research Centre for Living with Autism (Autism CRC)  Brisbane Queensland Australia"},{"name":"Telethon Kids Institute University of Western Australia  Subiaco Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2752-8345","authenticated-orcid":false,"given":"Kristelle","family":"Hudry","sequence":"additional","affiliation":[{"name":"School of Psychology and Public Health La Trobe University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the AICES Team","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10802-018-0453-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0b013e3181df7f3c"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1362361312442597"},{"key":"e_1_2_7_5_1","unstructured":"Barbaro J. Dissanayake C. &Sadka N. (2018).Universal developmental surveillance for autism in infants toddlers and preschoolers: The Social Attention and Communication Study\u2010Revised (SACS\u2010R) and SACS\u2010Preschool. Paper presented at the International Society for Autism Research (INSAR) Meeting Rotterdam Netherlands."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.chi.0000220849.48650.59"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/03630242.2011.540741"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-007-0440-y"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-015-2653-9"},{"key":"e_1_2_7_10_1","volume-title":"ITSEA: Infant\u2010toddler social and emotional assessment examiner's manual","author":"Carter A. S.","year":"2006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.20634"},{"key":"e_1_2_7_12_1","unstructured":"Chetcuti L. Uljarevi\u0107 M. Ellis\u2010Davies K Putnam S. Whitehouse A.J.O. Prior M.R. &Hudry K.(2019).Temperament in individuals with autism spectrum disorder: A systematic review. 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