{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:32:16Z","timestamp":1787495536061,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K23 MH092696"],"award-info":[{"award-number":["K23 MH092696"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH112734"],"award-info":[{"award-number":["R01 MH112734"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Impairments in inhibitory control are common in individuals with autism spectrum disorder (ASD) and associated with multiple clinical issues. Proactive (i.e., delaying response onset) and reactive control mechanisms (i.e., stopping quickly) contribute to successful inhibitory control in typically developing individuals and may be compromised in ASD. We assessed inhibitory control in 58 individuals with ASD and 63 typically developing controls aged 5\u201329\u2009years using an oculomotor stop\u2010signal task during which participants made rapid eye movements (i.e., saccades) toward peripheral targets (i.e., GO trials) or inhibited saccades (i.e., STOP trials). Individuals with ASD exhibited reduced ability to inhibit saccades, reduced reaction time slowing (GO RT slowing), and faster stop\u2010signal reaction times (SSRT) compared to controls. Across participants, stopping accuracy was positively related to GO RT slowing, and increased age was associated with higher stopping accuracy and GO RT slowing. Our results indicate that failures to proactively delay prepotent responses in ASD underpin deficits of inhibitory control and may contribute to difficulties modifying their behavior according to changes in contextual demands. These findings implicate frontostriatal brain networks in inhibitory control and core symptoms of ASD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay Summary<\/jats:title>\n                    <jats:p>Difficulties stopping actions are common in individuals with autism spectrum disorder (ASD) and are related to repetitive behaviors. This study compared the ability to stop eye movements in individuals with ASD and healthy peers. We found that individuals with ASD were less able to stop eye movements and that this difficulty was related to a reduced ability to delay their eye movements before seeing the cue to stop, not their ability to react quickly to this cue.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/aur.2415","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T04:16:13Z","timestamp":1603858573000},"page":"389-399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Reduced Proactive Control Processes Associated With Behavioral Response Inhibition Deficits in Autism Spectrum Disorder"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7879-4125","authenticated-orcid":false,"given":"Shannon E.","family":"Kelly","sequence":"first","affiliation":[{"name":"Clinical Child Psychology Program University of Kansas  Lawrence Kansas USA"},{"name":"Life Span Institute University of Kansas  Lawrence Kanas USA"},{"name":"Kansas Center for Autism Research and Training (KCART) University of Kansas  Lawrence, Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Division of Developmental and Behavioral Pediatrics Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Sweeney","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.","family":"Mosconi","sequence":"additional","affiliation":[{"name":"Clinical Child Psychology Program University of Kansas  Lawrence Kansas USA"},{"name":"Life Span Institute University of Kansas  Lawrence Kanas USA"},{"name":"Kansas Center for Autism Research and Training (KCART) University of Kansas  Lawrence, Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2014.07.017"},{"issue":"8","key":"e_1_2_7_3_1","first-page":"1","article-title":"Holm's sequential bonferroni procedure","volume":"1","author":"Abdi H.","year":"2010","journal-title":"Encyclopedia of Research Design"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10802-010-9420-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-011-1345-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.04.010"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.07.024"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1543-11.2011"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005596502855"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.114.2.376"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193779"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.10.029"},{"key":"e_1_2_7_13_1","volume-title":"Differential ability scales \u2013 II (DAS\u2010II)","author":"Elliott C. 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