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Reductions in GABA are proposed to result in an overly excitatory cortex that may cause, or contribute to, symptoms of autism spectrum disorder (ASD). This study employed a cross\u2010sectional design to explore GABA+ differences in ASD and the impact of age, comparing 4\u201312\u2009year olds with ASD (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a024) to typically developing children (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a035). GABA+ concentration was measured using edited magnetic resonance spectroscopy in the left parietal lobe. This study used a mixed model to investigate group differences between children with ASD and typically developing children. There was a significant difference in GABA+ levels between the groups, a significant effect of age and interaction between age and diagnostic group. The ASD group showed an association between GABA+ and age, with GABA+ levels gradually increasing with age (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.59,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003). Typically developing children did not show age\u2010related change in GABA+ concentration (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.09,\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u00a00.60). By the age of 9, children with ASD showed GABA+ levels that were comparable to their typically developing peers. This study suggests that children with ASD have initially lower levels of GABA+ in the left parietal lobe compared to typically developing children, and that these initially lower levels of GABA+ increase with age in ASD within this region. It is suggested that this developmental shift of GABA+ levels within the left parietal lobe provides a possible explanation for the previously found reductions in childhood that does not persist in adults.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay Summary<\/jats:title>\n                    <jats:p>\n                      This study measured levels of GABA in the left parietal lobe using magnetic resonance spectroscopy in children with ASD and typically developing children. GABA levels were initially lower in the ASD group, and increased with age, while GABA did not change with age in the typically developing group. This suggests that alterations in GABA signaling may be associated with ASD in childhood.\n                      <jats:italic>\n                        <jats:bold>Autism Res<\/jats:bold>\n                        2021, 14: 859\u2013872\n                      <\/jats:italic>\n                      . \u00a9 2021 International Society for Autism Research, Wiley Periodicals LLC.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/aur.2487","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T02:32:44Z","timestamp":1614306764000},"page":"859-872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Age\u2010related parietal\n                    <scp>GABA<\/scp>\n                    alterations in children with autism spectrum disorder"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9722-6027","authenticated-orcid":false,"given":"Marilena M.","family":"DeMayo","sequence":"first","affiliation":[{"name":"Brain and Mind Centre Children's Hospital Westmead Clinical School, Faculty of Medicine and Health, University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4731-7075","authenticated-orcid":false,"given":"Ashley D.","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Calgary  Calgary Canada"},{"name":"Alberta Children's Hospital Research University of Calgary  Calgary Canada"},{"name":"Hotchkiss Brain Institute University of Calgary  Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Ju C.","family":"Song","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre Faculty of Medicine and Health, University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabella","family":"Pokorski","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre Children's Hospital Westmead Clinical School, Faculty of Medicine and Health, University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinku","family":"Thapa","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre Children's Hospital Westmead Clinical School, Faculty of Medicine and Health, University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrujna","family":"Patel","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre Children's Hospital Westmead Clinical School, Faculty of Medicine and Health, University of Sydney  Sydney New South Wales 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