{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:50:57Z","timestamp":1762458657672},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T00:00:00Z","timestamp":1216339200000},"content-version":"vor","delay-in-days":47,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two single nucleotide polymorphisms (SNP) within Mitochondrial Aspartate\/Glutamate Carrier <jats:italic>SLC25A12<\/jats:italic> gene have recently shown to be strongly associated with autism. Here, we attempted to replicate this finding in two separate Finnish samples with autism spectrum disorders. Family\u2010based association analysis of two SNPs, rs2056202 and rs2292813, previously shown to be associated with autism was performed in two samples with different phenotypic characteristics. The samples included 97 families with strictly defined autism and 29 extended families with Asperger syndrome (AS). We detected association at rs2292813 (FBAT, <jats:italic>P<\/jats:italic>=0.0018) in the Finnish autism sample. In, addition other family\u2010based analysis methods supported this finding. By contrast, analysis of the AS sample yielded no evidence for association. This study shows further support that genetic variants within <jats:italic>SLC25A12<\/jats:italic> gene contribute to the etiology of autism.<\/jats:p>","DOI":"10.1002\/aur.25","type":"journal-article","created":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T19:11:25Z","timestamp":1216408285000},"page":"189-192","source":"Crossref","is-referenced-by-count":37,"title":["Mitochondrial aspartate\/glutamate carrier SLC25A12 gene is associated with autism"],"prefix":"10.1002","volume":"1","author":[{"given":"Joni A.","family":"Turunen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karola","family":"Rehnstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Kilpinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Kuokkanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elli","family":"Kempas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tero","family":"Ylisaukko\u2010oja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,18]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/342720"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700028099"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201444"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(02)02670-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/302845"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1375\/twin.8.1.16"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4002120"},{"key":"e_1_2_6_11_1","volume-title":"Diagnostic criteria for research","author":"World Health Organization","year":"1993"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.5.929"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.4.662"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2005.033621"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.11.2182"},{"key":"e_1_2_6_16_1","first-page":"408","article-title":"Autism\u2010related routines and rituals associated with a mitochondrial aspartate\/glutamate carrier SLC25A12 polymorphism","volume":"147","author":"Silverman J.M.","year":"2007","journal-title":"American Journal of Medical Genetics, B Neuropsychiatric Genetics"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001505"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001385"}],"container-title":["Autism Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Faur.25","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aur.25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T04:17:49Z","timestamp":1695961069000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/aur.25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1002\/aur.25"],"URL":"https:\/\/doi.org\/10.1002\/aur.25","archive":["Portico"],"relation":{},"ISSN":["1939-3792","1939-3806"],"issn-type":[{"value":"1939-3792","type":"print"},{"value":"1939-3806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}