{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:36:33Z","timestamp":1790807793070,"version":"4.1.0"},"reference-count":133,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T00:00:00Z","timestamp":1624665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T00:00:00Z","timestamp":1624665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012977","name":"Brescia University College","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003751","name":"Ministerio de Sanidad, Servicios Sociales e Igualdad","doi-asserted-by":"publisher","award":["PNSD2018\u2010050"],"award-info":[{"award-number":["PNSD2018\u2010050"]}],"id":[{"id":"10.13039\/501100003751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009740","name":"SUNY Downstate Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009740","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006251","name":"Universit\u00e9 de Bordeaux","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006251","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Clinical and preclinical findings have suggested a role of the endocannabinoid system (ECS) in the etiopathology of autism spectrum disorder (ASD). Previous mouse studies have investigated the role of ECS in several behavioral domains; however, none of them has performed an extensive assessment of social and communication behaviors, that is, the main core features of ASD. This study employed a mouse line lacking the primary endocannabinoid receptor (\n                      <jats:italic>CB1<\/jats:italic>\n                      r) and characterized ultrasonic communication and social interaction in\n                      <jats:italic>CB1<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>\u2212\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      <jats:italic>, CB1<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>+\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      , and\n                      <jats:italic>CB1<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>+\/+<\/jats:italic>\n                      <\/jats:sup>\n                      males and females. Quantitative and qualitative alterations in ultrasonic vocalizations (USVs) were observed in\n                      <jats:italic>CB1<\/jats:italic>\n                      null mice both during early development (i.e., between postnatal days 4 and 10), and at adulthood (i.e., at 3\u00a0months of age). Adult mutants also showed marked deficits in social interest in the three\u2010chamber test and social investigation in the direct social interaction test. These behavioral alterations were mostly observed in both sexes and appeared more marked in\n                      <jats:italic>CB1<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>\u2212\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      than\n                      <jats:italic>CB1<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>+\/\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      mutant mice. Importantly, the adult USV alterations could not be attributed to differences in anxiety or sensorimotor abilities, as assessed by the elevated plus maze and auditory startle tests. Our findings demonstrate the role of\n                      <jats:italic>CB1<\/jats:italic>\n                      r in social communication and behavior, supporting the use of the\n                      <jats:italic>CB1<\/jats:italic>\n                      full knockout mouse in preclinical research on these ASD\u2010relevant core domains.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay Summary<\/jats:title>\n                    <jats:p>The endocannabinoid system (ECS) is important for brain development and neural function and is therefore likely to be involved in neurodevelopmental disorders such as Autism Spectrum Disorder (ASD). Here we investigated changes in social behavior and communication, which are core features of ASD, in male and female mice lacking the chief receptor of this system. Our results show that loss of this receptor results in several changes in social behavior and communication both during early development and in adulthood, thus supporting the role of the ECS in these ASD\u2010core behavioral domains.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/aur.2562","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T05:14:15Z","timestamp":1624684455000},"page":"1854-1872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Communication and social interaction in the cannabinoid\u2010type 1 receptor null mouse: Implications for autism spectrum disorder"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8389-9899","authenticated-orcid":false,"given":"William","family":"Fyke","sequence":"first","affiliation":[{"name":"University of Bordeaux CNRS, EPHE, INCIA, UMR 5287  Bordeaux France"},{"name":"Graduate Program in Neural and Behavioral Science SUNY Downstate Medical Center  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Premoli","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Echeverry Alzate","sequence":"additional","affiliation":[{"name":"Department of Psychobiology and Methodology on Behavioral Sciences, Faculty of Psychology Madrid Complutense University  Spain"},{"name":"Unidad Gesti\u00f3n Cl\u00ednica de Salud Mental, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA) Hospital Regional Universitario de M\u00e1laga, Malaga University  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"L\u00f3pez\u2010Moreno","sequence":"additional","affiliation":[{"name":"Department of Psychobiology and Methodology on Behavioral Sciences, Faculty of Psychology Madrid Complutense University  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Lemaire\u2010Mayo","sequence":"additional","affiliation":[{"name":"University of Bordeaux CNRS, EPHE, INCIA, UMR 5287  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim E.","family":"Crusio","sequence":"additional","affiliation":[{"name":"University of Bordeaux CNRS, EPHE, INCIA, UMR 5287  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Marsicano","sequence":"additional","affiliation":[{"name":"University of Bordeaux, INSERM, U862 NeuroCentre Magendie Group Endocannabinoids and Neuroadaptation  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"W\u00f6hr","sequence":"additional","affiliation":[{"name":"KU Leuven, Faculty of Psychology and Educational Sciences, Research Unit Brain and Cognition, Laboratory of Biological Psychology Social and Affective Neuroscience Research Group  Leuven Belgium"},{"name":"KU Leuven Leuven Brain Institute  Leuven Belgium"},{"name":"Faculty of Psychology, Experimental and Biological Psychology, Behavioral Neuroscience Philipps\u2010University of Marburg  Marburg Germany"},{"name":"Center for Mind, Brain and Behavior Philipps\u2010University of Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8993-1922","authenticated-orcid":false,"given":"Susanna","family":"Pietropaolo","sequence":"additional","affiliation":[{"name":"University of Bordeaux CNRS, EPHE, INCIA, UMR 5287  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.05.067"},{"key":"e_1_2_7_3_1","unstructured":"Association A. P. (2013).Diagnostic and statistical manual of mental disorders (DSM\u20105\u00ae)."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37570-y"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.06.006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0376-6357(91)90086-F"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.04.016"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2494"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1137406"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(01)00277-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.10150"},{"key":"e_1_2_7_12_1","volume-title":"Handbook of mammalian vocalization: An integrative neuroscience approach","author":"Brudzynski S. M.","year":"2009"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1525066113"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142301.nsa04is48"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2020.06.011"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500x.119726"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(87)90096-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20039"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2007.00096.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)20023-2"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2008.00438.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv273"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1470919"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0681-12.2012"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.01.017"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyx014"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2010.01252.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.175"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.43.4.244"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.058206"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1977.tb00443.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2006.02.019"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-2999(01)00953-0"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-200509000-00016"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1814"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1743"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.11.027"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02192.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03293.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2009.0317"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040782"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026617"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1352\/2008.113:427-438"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-014-0124-6"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2014.03.008"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.05.056"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11689-020-09353-y"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2045"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-018-0203-y"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2016.07.008"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.5607\/en.2016.25.4.156"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2009.07.014"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12045"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00085.2010"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2017.03.013"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-26573-2_10"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7036.99.4.420"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2014.05.009"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035013"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00847.x"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00839"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2010.00029"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2007.00330.x"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(96)00511-0"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e32830ded11"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2007.01.020"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1006\/anbe.2000.1504"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-015-0003-6"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30081"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803545105"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.02.010"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2004.00071.x"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt079"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-1047(83)90722-7"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0077623"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.291"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.05.002"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2007.00102.x"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2020.04.016"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2014.07.021"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-009-9291-y"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019965"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.09.012"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.07.002"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017073"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9781107360556.014"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0333-8"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.08.024"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.04.034"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.12.041"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2008.08.003"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003067"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2010.00623.x"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.10.016"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11015"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1138659"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1280"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.11.036"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073814540521"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2013.12.007"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2851"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.11.008"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187926"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.168"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-3472(82)80161-9"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.2437"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1564"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2011.00049"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12561"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.09.016"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2017.06.012"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.301.3.915"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00057"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2017.02.005"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02247364"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2016.05.017"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001893"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(89)90164-9"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.07.013"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36232"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(97)00484-8"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0034899"},{"key":"e_1_2_7_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.03.021"},{"key":"e_1_2_7_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-008-9221-4"},{"key":"e_1_2_7_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.19"},{"key":"e_1_2_7_126_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020631"},{"key":"e_1_2_7_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.05.047"},{"key":"e_1_2_7_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.07.024"},{"key":"e_1_2_7_129_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6107-11.2012"},{"key":"e_1_2_7_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1465"},{"key":"e_1_2_7_131_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18091916"},{"key":"e_1_2_7_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3864"},{"key":"e_1_2_7_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(94)90181-3"},{"key":"e_1_2_7_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1098-2302(199703)30:2<141::aid-dev5>3.0.co;2-q"}],"container-title":["Autism Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aur.2562","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/aur.2562","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aur.2562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:07:55Z","timestamp":1773007675000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/aur.2562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,26]]},"references-count":133,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/aur.2562"],"URL":"https:\/\/doi.org\/10.1002\/aur.2562","archive":["Portico"],"relation":{},"ISSN":["1939-3792","1939-3806"],"issn-type":[{"value":"1939-3792","type":"print"},{"value":"1939-3806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,26]]},"assertion":[{"value":"2021-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}