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Even though these subgroups are considered as phenomenologically distinct in autism spectrum disorder (ASD) and obsessive\u2013compulsive disorder (OCD), brain imaging and genetic studies suggest that they have common mechanisms and pathways. This discrepancy may be explained by the frequent intellectual disability reported in ASD, which blurs the RB expressivity. Given the high heritability of RB, that is, the diversity of symptoms expressed in the relatives are dependent on those expressed in their probands, we hypothesize that if RB expressed in ASD or OCD are two distinct entities, then the RB expressed in relatives will also reflect these two dimensions. We thus conduct a linear discriminant analysis on RB in both the relatives of probands with ASD and OCD and subjects from the general population (<jats:italic>n<\/jats:italic>\u00a0=\u00a01023). The discriminant analysis results in a classification of 81.1% of the controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u200910<jats:sup>\u22124<\/jats:sup>), but poorly differentiated the ASD and OCD relatives (\u224846%). The stepwise analysis reveals that five symptoms attributed to high\u2010order RB and two related to low\u2010order RB (including hypersensitivity) are the most discriminant. Our results support the idea that the difference of RB patterns in the relatives is mild compared with the distribution of symptoms in controls. Our findings reinforce the evidence of a common biological pattern of RB both in ASD and OCD but with minor differences, specific to each of these two neuro\u2010developmental disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay summary<\/jats:title><jats:p>Repetitive behaviors (RB), a key symptom in the classification of both OCD and ASD, are phenomenologically considered as distinct in the two disorders, which is in contrast with brain imaging studies describing a common neural circuit. Intellectual disability, which is frequently associated with ASD, makes RB in ASD more difficult to understand as it affects the expression of the RB symptoms. To avoid this bias, we propose to consider the familial aggregation in ASD and OCD by exploring RB in the first\u2010degree relatives of ASD and OCD. Our results highlight the existence of RB expressed in relatives compared to the general population, with a common pattern of symptoms in relatives of both ASD and OCD but also minor differences, specific to each of these two neuro\u2010developmental disorders.<\/jats:p><\/jats:sec>","DOI":"10.1002\/aur.2570","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T07:45:23Z","timestamp":1626680723000},"page":"2373-2382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Discriminant value of repetitive behaviors in families with autism spectrum disorder and obsessional compulsive disorder probands"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8925-9219","authenticated-orcid":false,"given":"Aline","family":"Lefebvre","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Robert Debr\u00e9 Hospital, APHP  Paris France"},{"name":"Human Genetics and Cognitive Functions Institut Pasteur  Paris France"},{"name":"UMR3571 CNRS, Universite de Paris Paris 7 Denis Diderot University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Robert Debr\u00e9 Hospital, APHP  Paris France"},{"name":"Laboratoire de Sciences Cognitives et Psycholinguistique (ENS, EHESS, CNRS), Ecole Normale Sup\u00e9rieure PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Maruani","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Robert Debr\u00e9 Hospital, APHP  Paris France"},{"name":"Human Genetics and Cognitive Functions Institut Pasteur  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9derique","family":"Amsellem","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Robert Debr\u00e9 Hospital, APHP  Paris France"},{"name":"Human Genetics and Cognitive Functions Institut Pasteur  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Beggiato","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Robert Debr\u00e9 Hospital, APHP  Paris France"},{"name":"Human Genetics and Cognitive Functions Institut Pasteur  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouck","family":"Amestoy","sequence":"additional","affiliation":[{"name":"Autism Expert Centre Charles Perrens Hospital  Bordeaux France"},{"name":"Medical Sciences Department University of Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam Ly\u2010Le","family":"Moal","sequence":"additional","affiliation":[{"name":"Institut Roche Tour Horizons\u2010 Bureau 18M3  Boulogne\u2010Billancourt France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Umbricht","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development Roche Innovation Center Basel, F. Hoffmann\u2010La Roche Ltd.  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Chatham","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development Roche Innovation Center Basel, F. Hoffmann\u2010La Roche Ltd.  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Murtagh","sequence":"additional","affiliation":[{"name":"Roche Pharma Research and Early Development Roche Innovation Center Basel, F. Hoffmann\u2010La Roche Ltd.  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