{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:48:23Z","timestamp":1793245703467,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R102\u2010A9118"],"award-info":[{"award-number":["R102\u2010A9118"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R155\u20102014\u20101724"],"award-info":[{"award-number":["R155\u20102014\u20101724"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES026993"],"award-info":[{"award-number":["R01ES026993"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["1U01MH109514\u201001"],"award-info":[{"award-number":["1U01MH109514\u201001"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Psychiatric family history or a high autism polygenic risk score (PRS) have been separately linked to autism spectrum disorder (ASD) risk. The study aimed to simultaneously consider psychiatric family history and individual autism genetic liability (PRS) in autism risk. We performed a case\u2013control study of all Denmark singleton births, May 1981\u2013December 2005, in Denmark at their first birthday and a known mother. Cases were diagnosed with ASD before 2013 and controls comprised a random sample of 30,000 births without ASD, excluding persons with non\u2010Denmark\u2010born parents, missing ASD PRS, non\u2010European ancestry. Adjusted odds ratios (aOR) were estimated for ASD by PRS decile and by psychiatric history in parents or full siblings (8 mutually\u2010exclusive categories) using logistic regression. Adjusted ASD PRS\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score least\u2010squares means were estimated by psychiatric family history category. ASD risk (11,339 ASD cases; 20,175 controls) from ASD PRS was not substantially altered after accounting for psychiatric family history (e.g., ASD PRS 10th decile aOR: 2.35 (95% CI 2.11\u20132.63) before vs 2.11 (95% CI 1.91\u20132.40) after adjustment) nor from psychiatric family history after accounting for ASD PRS (e.g., ASD family history aOR: 6.73 (95% CI 5.89\u20137.68) before vs 6.32 (95% CI 5.53\u20137.22) after adjustment). ASD risk from ASD PRS varied slightly by psychiatric family history. While ASD risk from psychiatric family history was not accounted for by ASD PRS and vice versa, risk overlap between the two factors will likely increase as measures of genetic risk improve. The two factors are best viewed as complementary measures of family\u2010based autism risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay Summary<\/jats:title>\n                    <jats:p>Autism risk from a history of mental disorders in the immediate family was not explained by a measure of individual genetic risk (autism polygenic risk score) and vice versa. That is, genetic risk did not appear to overlap family history risk. As genetic measures for autism improve then the overlap in autism risk from family history versus genetic factors will likely increase, but further study may be needed to fully determine the components of risk and how they are inter\u2010related between these key family factors. Meanwhile, the two factors may be best viewed as complementary measures of autism family\u2010based risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/aur.2629","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T06:04:10Z","timestamp":1634796250000},"page":"171-182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Evaluating the interrelations between the autism polygenic score and psychiatric family history in risk for autism"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8588-1227","authenticated-orcid":false,"given":"Diana","family":"Schendel","sequence":"first","affiliation":[{"name":"The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH  Aarhus Denmark"},{"name":"Department of Public Health Aarhus University  Aarhus Denmark"},{"name":"National Centre for Register\u2010Based Research (NCRR), Department of Economics and Business Aarhus University  Aarhus Denmark"},{"name":"A. J. Drexel Autism Institute Drexel University  Philadelphia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Munk Laursen","sequence":"additional","affiliation":[{"name":"The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH  Aarhus Denmark"},{"name":"National Centre for Register\u2010Based Research (NCRR), Department of Economics and Business Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Albi\u00f1ana","sequence":"additional","affiliation":[{"name":"The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH  Aarhus Denmark"},{"name":"National Centre for Register\u2010Based Research (NCRR), Department of Economics and Business Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarni","family":"Vilhjalmsson","sequence":"additional","affiliation":[{"name":"The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH  Aarhus Denmark"},{"name":"National Centre for Register\u2010Based Research (NCRR), Department of Economics and Business Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Ladd\u2010Acosta","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret Danielle","family":"Fallin","sequence":"additional","affiliation":[{"name":"Wendy Klag Center for Autism and Developmental Disabilities Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"},{"name":"Department of Mental Health Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Benke","sequence":"additional","affiliation":[{"name":"Department of Mental Health Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Lee","sequence":"additional","affiliation":[{"name":"A. J. Drexel Autism Institute Drexel University  Philadelphia USA"},{"name":"Drexel University Dornsife School of Public Health  Philadelphia USA"},{"name":"Department of Public Health Sciences Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Grove","sequence":"additional","affiliation":[{"name":"The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH  Aarhus Denmark"},{"name":"Centre for Integrative Sequencing, iSEQ Aarhus University  Aarhus Denmark"},{"name":"Department of Biomedicine \u2013 Human Genetics Aarhus University  Aarhus Denmark"},{"name":"Bioinformatics Research Centre Aarhus University  Aarhus Denmark"},{"name":"Centre for Genomics and Personalized Medicine  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Kalkbrenner","sequence":"additional","affiliation":[{"name":"University of Wisconsin Milwaukee Joseph J Zilber School of Public Health  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Ejlskov","sequence":"additional","affiliation":[{"name":"The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH  Aarhus Denmark"},{"name":"National Centre for Register\u2010Based Research (NCRR), Department of Economics and Business Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hougaard","sequence":"additional","affiliation":[{"name":"Center for Neonatal Screening, Department for Congenital Disorders Statens Serum Institut  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Bybjerg\u2010Grauholm","sequence":"additional","affiliation":[{"name":"Center for Neonatal Screening, Department for Congenital Disorders Statens Serum Institut  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"B\u00e6kvad\u2010Hansen","sequence":"additional","affiliation":[{"name":"Center for Neonatal Screening, Department for Congenital Disorders Statens Serum Institut  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders D.","family":"B\u00f8rglum","sequence":"additional","affiliation":[{"name":"The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH  Aarhus Denmark"},{"name":"Centre for Integrative Sequencing, iSEQ Aarhus University  Aarhus Denmark"},{"name":"Department of Biomedicine \u2013 Human Genetics Aarhus University  Aarhus Denmark"},{"name":"Centre for Genomics and Personalized Medicine  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Werge","sequence":"additional","affiliation":[{"name":"The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH  Aarhus Denmark"},{"name":"Institute of Biological Psychiatry, MHC Sct. 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