{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:18:15Z","timestamp":1771049895989,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T00:00:00Z","timestamp":1640304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>This study evaluated the association between placental pathology and gross morphology and the risk of autism spectrum disorders (ASD). We conducted a matched case\u2013control study of children with confirmed ASD who were born between 2000 and 2017 at one of three university\u2010affiliated hospitals in Montreal, Quebec. Cases, who were identified through the Montreal Children's Hospital Autism Spectrum Disorders Program, were matched to babies (1:5) born at the same hospital and on the same day. Multi\u2010fetal births were excluded. Maternal demographics, pregnancy characteristics and placental pathologies were collected from hospital charts by abstractors blind to autism diagnoses. This current study consisted of data from a single\u2010site that had pathology reports available. Pearson chi\u2010square and Wilcoxon rank\u2010sum tests were used to estimate <jats:italic>p<\/jats:italic>\u2010values. Our study consisted of 107 ASD cases and 526 matched controls. Mothers of cases and controls were similar in terms of parity, gravidity, smoking status, BMI, rates of clinical chorioamnionitis, chronic hypertension, and gestational diabetes. Age at delivery of &lt;25\u2009years was more common among mothers of controls. Compared with controls, cases were more likely born male, &lt;32\u2009weeks of gestation, and weighing &lt;1500\u2009g. Cases and controls had similar rates of placental inflammation, vasculitis, and other placental pathologies. There were no differences in placental weight, placental thickness, umbilical cord length, and umbilical cord insertion between the two groups. In conclusion, placental pathology and gross morphology do not appear to be associated with ASD, suggesting that any perinatal determinants of autism are not likely to be mediated through placental pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay Summary<\/jats:title><jats:p>Data from a matched case\u2013control study consisting of neonates born between 2000 and 2017 at one of three McGill\u2010affiliated hospitals were used to examine the relationship between placental pathology and morphology and the development of autism. No differences in placental pathology and gross morphology were found between those with and without autism, which suggests that placental abnormalities are unlikely to either cause or mediate the development of autism.<\/jats:p><\/jats:sec>","DOI":"10.1002\/aur.2658","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T11:33:51Z","timestamp":1640345631000},"page":"531-538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of placental pathology and gross morphology with autism spectrum disorders"],"prefix":"10.1002","volume":"15","author":[{"given":"Safiya","family":"Soullane","sequence":"first","affiliation":[{"name":"Faculty of Medicine McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea R.","family":"Spence","sequence":"additional","affiliation":[{"name":"Centre for Clinical Epidemiology and Community 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