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Most work has investigated CHD\u2010related neurodevelopmental abnormalities. Cardiac abnormalities in ASD have been less studied. We investigated the prevalence of cardiac comorbidities relative to ASD genetic contributors. Using high frequency ultrasound imaging, we screened 9 ASD\u2010related genetic mouse models (\n                      <jats:italic>Arid1b<\/jats:italic>\n                      <jats:sup>(+\/\u2212)<\/jats:sup>\n                      ,\n                      <jats:italic>Chd8<\/jats:italic>\n                      <jats:sup>(+\/\u2212)<\/jats:sup>\n                      , 16p11.2 (deletion),\n                      <jats:italic>Sgsh<\/jats:italic>\n                      <jats:sup>(+\/\u2212)<\/jats:sup>\n                      ,\n                      <jats:italic>Sgsh<\/jats:italic>\n                      <jats:sup>(\u2212\/\u2212)<\/jats:sup>\n                      ,\n                      <jats:italic>Shank3 \u0394exon 4\u20139<\/jats:italic>\n                      <jats:sup>(+\/\u2212)<\/jats:sup>\n                      ,\n                      <jats:italic>Shank3 \u0394exon 4\u20139<\/jats:italic>\n                      <jats:sup>(\u2212\/\u2212)<\/jats:sup>\n                      ,\n                      <jats:italic>Fmr1<\/jats:italic>\n                      <jats:sup>(\u2212\/\u2212)<\/jats:sup>\n                      ,\n                      <jats:italic>Vps13b<\/jats:italic>\n                      <jats:sup>(+\/\u2212)<\/jats:sup>\n                      ), and pooled wild\u2010type littermates (WTs). We measured heart rate (HR), aorta diameter (AoD), thickness and thickening of the left\u2010ventricular (LV) anterior and posterior walls, LV chamber diameter, fractional shortening, stroke volume and cardiac output, mitral inflow Peak E and A velocity ratio, ascending aorta velocity time integral (VTI). Mutant groups presented small\u2010scale alterations in cardiac structure and function compared to WTs (LV anterior wall thickness and thickening, chamber diameter and fractional shortening, HR). A greater number of significant differences was observed among mutant groups than between mutant groups and WTs. Mutant groups differed primarily in structural measures (LV chamber diameter and anterior wall thickness, HR, AoD). The mutant groups with most differences to WTs were 16p11.2 (deletion),\n                      <jats:italic>Fmr1<\/jats:italic>\n                      <jats:sup>(\u2212\/\u2212)<\/jats:sup>\n                      ,\n                      <jats:italic>Arid1b<\/jats:italic>\n                      <jats:sup>(+\/\u2212)<\/jats:sup>\n                      . The mutant groups with most differences from other mutant groups were 16p11.2 (deletion),\n                      <jats:italic>Sgsh<\/jats:italic>\n                      <jats:sup>(+\/\u2212)<\/jats:sup>\n                      ,\n                      <jats:italic>Fmr1<\/jats:italic>\n                      <jats:sup>(\u2212\/\u2212)<\/jats:sup>\n                      . Our results recapitulate the associated clinical findings. The characteristic ASD heterogeneity was recapitulated in the cardiac phenotype. The type of abnormal measures (morphological, functional) can highlight common underlying mechanisms. Clinically, knowledge of cardiac abnormalities in ASD can be essential as even non\u2010lethal abnormalities impact normal development.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay Summary<\/jats:title>\n                    <jats:p>Autism spectrum disorder (ASD) and congenital heart disease (CHD) are linked functionally and genetically. ASD cardiac phenotyping is limited. We assessed the cardiac phenotype of 9 ASD\u2010related mouse models. We found subtle heterogenous cardiac abnormalities compared to controls, with more differences within ASD than between ASD and controls, mirroring clinical findings. Clinically, knowing the cardiac abnormalities in ASD is vital as even non\u2010lethal cardiac abnormalities can impact development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/aur.2728","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T07:54:23Z","timestamp":1650527663000},"page":"1189-1208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7321-6297","authenticated-orcid":false,"given":"Stephania","family":"Assimopoulos","sequence":"first","affiliation":[{"name":"Mouse Imaging Centre Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Sickkids Research Institute, The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Department of Medical Biophysics University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9823-2827","authenticated-orcid":false,"given":"Christopher","family":"Hammill","sequence":"additional","affiliation":[{"name":"Mouse Imaging Centre Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Sickkids Research Institute, The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren J.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Mouse Imaging Centre Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Sickkids Research Institute, The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara Leigh","family":"Spencer Noakes","sequence":"additional","affiliation":[{"name":"Mouse Imaging Centre Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Sickkids Research Institute, The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Qing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Mouse Imaging Centre Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9619-146X","authenticated-orcid":false,"given":"Lauryl M. 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