{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:02:24Z","timestamp":1791316944362,"version":"4.3.1"},"reference-count":112,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR000445"],"award-info":[{"award-number":["UL1 TR000445"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH111599"],"award-info":[{"award-number":["MH111599"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Autism spectrum disorder (ASD) is characterized by impaired social communication and poor adaptation to change; thus, pubertal development may be precarious. Pubertal timing and tempo were measured in 244 youth (7.9% Black, 83.3% White, and 8.7% multiracial) with ASD (<jats:italic>N<\/jats:italic>\u00a0=\u00a0140) and typical development (<jats:italic>N<\/jats:italic>\u00a0=\u00a0104). Pubertal development was measured using Tanner staging of Genital (G, males), Breast (B, females), and pubic hair (PH) in both sexes at Year 1 (10\u201313\u2009years), Year 2 (11\u201314\u2009years), and Year 3 (12\u201315\u2009years). Nonlinear mixed effects models analyzed interindividual differences in timing and tempo. For both sexes, ASD and higher body mass index were associated with earlier pubertal timing. Males generally exhibited faster tempo than females. Linear regression models did not show associations between pubertal timing and internalizing symptoms at time three. Findings showing advanced pubertal maturation in ASD youth suggest greater risk of psychological, social, and physiological challenges.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay Summary<\/jats:title><jats:p>Youth with ASD have difficulty in social communication and adaption to change, thus puberty may be a challenging transition. The study examined onset (timing) and progression (tempo) of puberty over three years, using physical exam, in 244 adolescents with and without ASD, enrolled at ages 10\u201313. ASD youth started puberty earlier, while males generally progressed at a faster pace. Further examination of puberty in ASD should identify impact on social, behavioral, and mental health outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/aur.2786","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T10:48:16Z","timestamp":1659350896000},"page":"1894-1908","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Examination of pubertal timing and tempo in females and males with autism spectrum disorder compared to typically developing youth"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2165-8015","authenticated-orcid":false,"given":"Blythe A.","family":"Corbett","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Vanderbilt Kennedy Center Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Psychology Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9862-1686","authenticated-orcid":false,"given":"Rachael A.","family":"Muscatello","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahra","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Vandekar","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Duffus","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sloane","family":"Sparks","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5395-9659","authenticated-orcid":false,"given":"Yasas","family":"Tanguturi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Manual for the ASEBA school\u2010age forms & profiles","author":"Achenbach T. M.","year":"2001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(03)00005-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.75.4.594"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1352\/1944-7558-116.5.381"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10802-009-9326-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/s003329170300775x"},{"key":"e_1_2_8_8_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"APA","year":"2013"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-57-1-82"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5014\/ajot.37.8.535"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1584"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0038096"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp181"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-005-3302-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-3079"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.10.020"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.114476"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.105"},{"issue":"1","key":"e_1_2_8_19_1","first-page":"79","article-title":"Adolescent development of children with infantile psychosis","volume":"1","author":"Brown J. L.","year":"1969","journal-title":"Seminars in Psychiatry"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.1813E"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2009.04.005"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/1054-139x(93)90004-9"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1037\/\/0022-3514.61.1.157"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-3-199808010-00012"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579409000327"},{"key":"e_1_2_8_26_1","unstructured":"Corbett B. A.(2017).Examining stress and arousal across pubertal development in ASD[Grant]."},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-020-04749-0"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-020-04749-0"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-019-04192-w"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-3-13"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-1-13"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12184"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.2406"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/1362361316683888"},{"key":"e_1_2_8_35_1","unstructured":"Crockett L. J.(1988).Pubertal development scale: Pubertal categories."},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-10-11"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1308.001"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1207\/s1532480xads1001_3"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2019.5881"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.112.8.607"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2009.10.007"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1037\/\/0012-1649.38.1.42"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1037\/0012-1649.37.3.404"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01531612"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01495061"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014826"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cd.23219967104"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199712000-00026"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.06.017"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/10705510903206055"},{"issue":"6","key":"e_1_2_8_51_1","first-page":"1","article-title":"Prevalence of autism Spectrum disorder among children aged 8\u2009years\u2013autism and developmental disabilities monitoring network, 11 sites, United States, 2014","volume":"67","author":"Hales C. M.","year":"2018","journal-title":"NCHS Data Brief"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2011.01.015"},{"issue":"2","key":"e_1_2_8_53_1","first-page":"110","article-title":"Physical growth and development in a sample of autistic girls from New South Wales","volume":"15","author":"Harper J. F.","year":"1979","journal-title":"Australian Paediatric Journal"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/1362361318791817"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.22739"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.4.505"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-3291"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-1437"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2009.02.013"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(02)00480-X"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.593"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2014.08.013"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.10101532"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162206222229"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2019.11.308"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10567-013-0148-9"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0070(80)80005-2"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272431611429945"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2017.03.013"},{"key":"e_1_2_8_70_1","volume-title":"Autism diagnostic observation schedule (ADOS\u20102)","author":"Lord C.","year":"2012"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss6904a1"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-011-1356-0"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0023838"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21214"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.44.235.291"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.45.239.13"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-017-3281-3"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/jora.12371"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0020205"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dr.2006.11.001"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02211853"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/jora.12128"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323000803600208"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.9.7863"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1096-7192(03)00107-0"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00598.x"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.50.6.661"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01537962"},{"key":"e_1_2_8_89_1","volume-title":"Handbook of adolescent psychology","author":"Petersen A. C.","year":"1980"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-014-1442-y"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1177\/2167702614540646"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-5-27"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01537183"},{"issue":"4","key":"e_1_2_8_94_1","first-page":"435","article-title":"Autistic children\u2013infancy to adulthood","volume":"2","author":"Rutter M.","year":"1970","journal-title":"Seminars in Psychiatry"},{"key":"e_1_2_8_95_1","volume-title":"The social communication questionnaire","author":"Rutter M.","year":"2003"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20038"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8624.2009.01263.x"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1326"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(00)00014-2"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2004.12.005"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.09.004"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1709"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-010-1005-z"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.11.1626-a"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.13203"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.151u151"},{"key":"e_1_2_8_107_1","volume-title":"Wechsler abbreviated scale of intelligence II","author":"Wechsler D.","year":"2011"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0955"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-010-1129-1"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200x.2004.01946.x"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00035"},{"issue":"24","key":"e_1_2_8_112_1","first-page":"55","article-title":"Three patients with autism and central precocious puberty","volume":"14","author":"Yoshirmura K.","year":"2005","journal-title":"Clinical Pediatrics Endocrinology"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-014-2050-9"}],"container-title":["Autism Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aur.2786","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/aur.2786","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aur.2786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T17:09:42Z","timestamp":1692637782000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/aur.2786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":112,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/aur.2786"],"URL":"https:\/\/doi.org\/10.1002\/aur.2786","archive":["Portico"],"relation":{},"ISSN":["1939-3792","1939-3806"],"issn-type":[{"value":"1939-3792","type":"print"},{"value":"1939-3806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"2022-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}