{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T14:10:16Z","timestamp":1778595016149,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010846","name":"Health and Family Planning Commission of Hubei Province","doi-asserted-by":"publisher","award":["WJ2019H299"],"award-info":[{"award-number":["WJ2019H299"]}],"id":[{"id":"10.13039\/501100010846","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>This study of infants from Hubei Province, China examined brainstem auditory evoked potentials (BAEP) and mental development index (MDI) as possible early indicators associated with autism spectrum disorders (ASD). The 34 ASD cases and 102 controls who had recovered from perinatal conditions were matched for age, sex, gestational age, birth weight and maternal age. BAEP absolute latencies (AL) I, III, V and interpeak latencies (IPL) I\u2010III, III\u2010V, I\u2010V were compared in ASD cases and controls at ages 1, 3 and 6\u00a0months. MDI scores were compared in these infants from 1\u00a0month to 2\u2009years old. Multiple logistic regression analysis was performed to test associations among ASD, BAEP and MDI. Results showed BAEP AL I, V and IPL III\u2010V prolonged in the ASD group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and MDI scores in ASD cases sharply declining from 12 to 24\u2009months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Regression analysis revealed odds ratios (OR) indicating that ASD was likely associated with abnormal values of BAEP AL I at 1 and 3\u00a0months (OR<jats:sub>AL I<\/jats:sub>: 4.27; OR<jats:sub>AL I<\/jats:sub>: 4.13), and AL V at 6\u00a0months (OR<jats:sub>AL V<\/jats:sub>: 7.85). Lower MDI scores (MDI\u2009&lt;\u200980) in infants at 1, 3, and 6\u00a0months were likely associated with ASD (OR<jats:sub>MDI<\/jats:sub>: 2.58; OR<jats:sub>MDI<\/jats:sub>: 3.83; OR<jats:sub>MDI<\/jats:sub>: 4.87). These data show that abnormal BAEP values and low MDI scores are independent factors associated with ASD, and that monitoring of BAEP and MDI during infancy might facilitate screening for ASD development.<\/jats:p><\/jats:sec>","DOI":"10.1002\/aur.2821","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T13:25:21Z","timestamp":1663853121000},"page":"2012-2025","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploring brainstem auditory evoked potentials and mental development index as early indicators of autism spectrum disorders in <scp>high\u2010risk<\/scp> infants"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3876-6162","authenticated-orcid":false,"given":"Xiaoyan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Child Health Care Maternal and Child Health Hospital of Hubei Province  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5030-0269","authenticated-orcid":false,"given":"Xianming","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Public Health Mercer University College of Health Professions  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Child Health Care Maternal and Child Health Hospital of Hubei Province  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Baptist","family":"du Prel","sequence":"additional","affiliation":[{"name":"Department of Occupational Health Science University of Wuppertal  Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Child Health Care Maternal and Child Health Hospital of Hubei Province  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Child Health Care Maternal and Child Health Hospital of Hubei Province  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Leeper\u2010Woodford","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Mercer University School of Medicine  Macon Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0236994"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and statistical manual of mental disorders (DSM\u20105\u00ae)","author":"American Psychiatric Association","year":"2013"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171400172X"},{"key":"e_1_2_8_5_1","volume-title":"Bayley scales of infant development","author":"Bayley N.","year":"1993"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00508"},{"key":"e_1_2_8_7_1","first-page":"32","article-title":"International statistical classification of diseases and related health problems","volume":"41","author":"Br\u00e4mer G. 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