{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T13:05:21Z","timestamp":1765976721221,"version":"3.40.5"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022B1515130007"],"award-info":[{"award-number":["2022B1515130007"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003482"],"award-info":[{"award-number":["82003482"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is limited evidence on the associations of unintended pregnancy with autism spectrum disorders (ASD). This study aimed to examine this relationship and the modification of pre\u2010conceptional and prenatal folic acid supplements. Six thousand and five toddlers aged 16 to 30\u2009months from seven cities of six provinces in China were eligible for participation. Information on unintended pregnancy and folic acid supplements was obtained via questionnaires from caregivers of toddlers. The diagnosis of ASD was based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM\u20105) and the Chinese version of the Childhood Autism Rating Scale (CARS). Of the 6005 toddlers in the study (3337 boys and 2668 girls), 71 (1.18%) received the diagnosis of ASD. Generalized linear models with a logit link function showed unintended pregnancy was positively associated with ASD (odds ratios [OR]\u2009=\u20091.69, 95% confidence interval [CI], 1.05\u20132.79). Stratified estimates indicated that the association remained stable among toddlers of mothers without pre\u2010conceptional and prenatal folic acid supplements (OR\u2009=\u20092.75, 95% CI, 1.04\u20137.27; <jats:italic>n<\/jats:italic>\u2009=\u20091243, 20.70%). Unintended pregnancy was associated with higher odds of ASD in 16\u201330\u2009months of toddlers, and the association was consistent among toddlers of mothers without prenatal folic acid supplements. Our findings emphasize the need to raise awareness of the risk of unintended pregnancy and the benefits of folic acid supplements among Chinese women.<\/jats:p>","DOI":"10.1002\/aur.3070","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T12:54:35Z","timestamp":1703249675000},"page":"172-181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations of unintended pregnancy with autism spectrum disorders and the modification of folic acid supplements"],"prefix":"10.1002","volume":"17","author":[{"given":"Qian","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neonatology, Guangzhou Key Laboratory of Neonatal Intestinal Diseases The Third Affiliated Hospital of Guangzhou Medical University  Guangzhou Guangdong People's Republic of 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