{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:20:03Z","timestamp":1781018403435,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011878","name":"Vlaamse regering","doi-asserted-by":"publisher","award":["METH\/14\/02"],"award-info":[{"award-number":["METH\/14\/02"]}],"id":[{"id":"10.13039\/501100011878","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mechanisms underlying atypical sensory processing in autism remain to be elucidated, but research points toward a role of the glutamatergic\/GABAergic balance. To investigate the potential relationships between visual sensitivity and its molecular correlates in autism, we combined data from electroencephalography (EEG) and magnetic resonance spectroscopy (MRS) studies. Twenty autistic adults and sixteen neurotypical adults (NT) participated in both an EEG study assessing visual sensitivity (Sapey\u2010Triomphe et al., <jats:italic>Autism Research<\/jats:italic>, 2023) and in an MRS study measuring Glx and GABA+ concentrations in the occipital cortex (Sapey\u2010Triomphe et al., <jats:italic>Molecular Autism<\/jats:italic>, 2021). These studies revealed no group differences in neural detection thresholds or in Glx\/GABA levels in the occipital cortex. Neural detection thresholds for contrast and spatial frequency (SF) were determined using fast periodic visual stimulations and neural frequency tagging. In the present study, Glx\/GABA+ concentrations in the occipital cortex and neural detection thresholds did not differ between groups. Interestingly, lower Glx\/GABA+ ratios were associated with lower contrast detection thresholds and higher SF detection thresholds. These correlations were also significant within the neurotypical and autistic groups. This report suggests that the Glx\/GABA balance regulates visual detection thresholds across individuals. In both autistic and NTs, lower Glx\/GABA ratios in the occipital cortex allow for better detection of visual inputs at the neural level. This study sheds light on the neurochemical underpinnings of visual sensitivity in autism and warrants further investigation.<\/jats:p>","DOI":"10.1002\/aur.3130","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T06:40:15Z","timestamp":1712299215000},"page":"917-922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>GABA<\/scp> and <scp>Glx<\/scp> predict <scp>EEG<\/scp> responses of visual sensitivity in autism"],"prefix":"10.1002","volume":"17","author":[{"given":"Laurie\u2010Anne","family":"Sapey\u2010Triomphe","sequence":"first","affiliation":[{"name":"Department of Brain and Cognition Leuven Brain Institute, KU Leuven  Leuven Belgium"},{"name":"Universit\u00e9 Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, CAP Team  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaas A. J.","family":"Puts","sequence":"additional","affiliation":[{"name":"Department of Forensic and Neurodevelopmental Sciences and the Institute of Psychiatry, Psychology, and Neuroscience Sackler Institute for Translational Neurodevelopment, King's College London  London UK"},{"name":"MRC Centre for Neurodevelopmental Disorders, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago L.","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Brain and Cognition Leuven Brain Institute, KU Leuven  Leuven Belgium"},{"name":"Department of Neurosciences, Biomedicine and Movement Sciences University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Wagemans","sequence":"additional","affiliation":[{"name":"Department of Brain and Cognition Leuven Brain Institute, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27702"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26233"},{"key":"e_1_2_11_4_1","first-page":"579","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_11_5_1","unstructured":"Costa T. 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