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Therefore, efforts to examine transdiagnostic factors (i.e., distress tolerance, behavioral activation) may afford more parsimonious means for assessment and treatment. To our knowledge, there has been little research on distress tolerance, behavioral activation, and depressive and anxiety symptoms in autistic adolescents to guide diagnostic practices and treatment planning. In the current study, we examined the interrelationships between these transdiagnostic factors and depressive and anxiety symptoms using ratings from 100 verbally fluent autistic adolescents without intellectual disability (<jats:italic>M<\/jats:italic><jats:sub>age<\/jats:sub>\u2009=\u200913.70, SD<jats:sub>age<\/jats:sub>\u2009=\u20092.23, Range: 11:00\u201317:11\u2009years) and 100 of their caregivers. Many adolescents reported male sex assigned at birth (61%), cisgender (87%), not Hispanic\/Latinx (90%), and White (80%) identities. A series of correlational analyses were employed to examine associations between these constructs from youth and caregiver perspectives, and multiple linear regression analyses were conducted to explore the mediating roles of distress tolerance and behavioral activation. Preliminary results show that low distress tolerance and behavioral activation were associated with more severe internalizing symptoms per self\u2010 and caregiver\u2010report. Some differences by rater emerged, which highlight the importance of multi\u2010informant ratings in autism. Results from mediation analyses may show that behavioral activation may be more salient to assessments and treatment planning for depression than distress tolerance, while distress tolerance may be important for both anxiety and depression; however, findings are preliminary given the cross\u2010sectional nature of the data. Findings suggest that these transdiagnostic concepts may be important to individualizing treatment approaches, including the timing of certain approaches, for anxiety and\/or depression in autistic adolescents.<\/jats:p>","DOI":"10.1002\/aur.3208","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T09:25:01Z","timestamp":1722936301000},"page":"2278-2291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The relationship between distress tolerance and behavioral activation on anxiety and depression symptomatology in autistic youth: Leveraging self and caregiver perspectives"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9534-7773","authenticated-orcid":false,"given":"Jessica M.","family":"Schwartzman","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Pediatrics University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0603-9371","authenticated-orcid":false,"given":"Ligia","family":"Antezana","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6224-2086","authenticated-orcid":false,"given":"Caitlin M.","family":"Conner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"issue":"3","key":"e_1_2_9_2_1","first-page":"261","article-title":"Emotion regulation strategies as transdiagnostic processes: A closer look at the invariance of their form and function","volume":"17","author":"Aldao A.","year":"2012","journal-title":"Spanish Journal of Clinical Psychology"},{"key":"e_1_2_9_3_1","volume-title":"Mechanisms of change in behavioral activation: Adapting depression treatment for autistic people","author":"Bal V. 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