{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:01:57Z","timestamp":1772118117884,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R102\u2010A9118"],"award-info":[{"award-number":["R102\u2010A9118"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R155\u20102014\u20101724"],"award-info":[{"award-number":["R155\u20102014\u20101724"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES026993"],"award-info":[{"award-number":["R01ES026993"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The relatively few conditions and family member types (e.g., sibling, parent) considered in investigations of family health history in autism spectrum disorder (ASD, or autism) limits understanding of the role of family history in autism etiology. For more comprehensive understanding and hypothesis\u2010generation, we produced an open\u2010source catalog of autism associations with family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions. All live births in Denmark, 1980\u20132012, of Denmark\u2010born parents (1,697,231 births), and their 3\u2010generation family members were followed through April 10, 2017 for each of 90 diagnoses (including autism), emigration or death. Adjusted hazard ratios (aHR) were estimated via Cox regression for each diagnosis\u2010family member type combination, adjusting for birth year, sex, birth weight, gestational age, parental ages at birth, and number of family member types of index person; aHRs also calculated for sex\u2010specific co\u2010occurrence of each disorder. We obtained 6462 individual family history aHRS across autism overall (26,840 autistic persons; 1.6% of births), by sex, and considering intellectual disability (ID); and 350 individual co\u2010occurrence aHRS. Results are cataloged in interactive heat maps and down\u2010loadable data files:\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/ncrr-au.shinyapps.io\/asd-riskatlas\/\">https:\/\/ncrr-au.shinyapps.io\/asd-riskatlas\/<\/jats:ext-link>\n                    and interactive graphic summaries:\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/public.tableau.com\/app\/profile\/diana.schendel\/viz\/ASDPlots_16918786403110\/e-Figure5\">https:\/\/public.tableau.com\/app\/profile\/diana.schendel\/viz\/ASDPlots_16918786403110\/e-Figure5<\/jats:ext-link>\n                    .\n                  <\/jats:p>\n                  <jats:p>While primarily for reference material or use in other studies (e.g., meta\u2010analyses), results revealed considerable breadth and variation in magnitude of familial health history associations with autism by type of condition, family member type, sex of the family member, side of the family, sex of the index person, and ID status, indicative of diverse genetic, familial, and nongenetic autism etiologic pathways. Careful attention to sources of autism likelihood in family health history, aided by our open data resource, may accelerate understanding of factors underlying neurodiversity.<\/jats:p>","DOI":"10.1002\/aur.3232","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T08:20:49Z","timestamp":1726474849000},"page":"2144-2155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["3\u2010generation family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions associated with autism: An open\u2010source catalog of findings"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8588-1227","authenticated-orcid":false,"given":"Diana","family":"Schendel","sequence":"first","affiliation":[{"name":"A.J. Drexel Autism Institute, Drexel University  Philadelphia Pennsylvania USA"},{"name":"The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH  Aarhus Denmark"},{"name":"National Centre for Register\u2010Based Research, Aarhus BSS, Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Ejlskov","sequence":"additional","affiliation":[{"name":"The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH  Aarhus Denmark"},{"name":"National Centre for Register\u2010Based Research, Aarhus BSS, Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Overgaard","sequence":"additional","affiliation":[{"name":"Department of Public Health Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeal","family":"Jinwala","sequence":"additional","affiliation":[{"name":"A.J. Drexel Autism Institute, Drexel University  Philadelphia Pennsylvania USA"},{"name":"School of Biomedical Engineering, Science and Health Systems Drexel University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor","family":"Kim","sequence":"additional","affiliation":[{"name":"A.J. Drexel Autism Institute, Drexel University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Parner","sequence":"additional","affiliation":[{"name":"Department of Public Health Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy E.","family":"Kalkbrenner","sequence":"additional","affiliation":[{"name":"University of Wisconsin Milwaukee, Joseph J Zilber College of Public Health  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Ladd Acosta","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Danielle","family":"Fallin","sequence":"additional","affiliation":[{"name":"Wendy Klag Center for Autism and Developmental Disabilities Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"},{"name":"Department of Mental Health Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9887-7596","authenticated-orcid":false,"given":"Sherlly","family":"Xie","sequence":"additional","affiliation":[{"name":"Dornsife School of Public Health Drexel University  Philadelphia Pennsylvania USA"},{"name":"Medtronic, Mounds View  Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preben Bo","family":"Mortensen","sequence":"additional","affiliation":[{"name":"The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH  Aarhus Denmark"},{"name":"National Centre for Register\u2010Based Research, Aarhus BSS, Aarhus University  Aarhus Denmark"},{"name":"Centre for Integrated Register\u2010based Research Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3635-8034","authenticated-orcid":false,"given":"Brian K.","family":"Lee","sequence":"additional","affiliation":[{"name":"A.J. 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