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We examined whether associations of maternal cannabis use from 3\u2009months preconception through delivery (\u201cperipregnancy\u201d) with behavior and development in the offspring varied with the presence of ASD symptoms. Children ages 30\u201368\u2009months with ASD symptoms (i.e., met study criteria for ASD or had ASD symptoms on standardized assessments or community ASD diagnosis, <jats:italic>N<\/jats:italic>\u2009=\u20092734) and without ASD symptoms (other developmental delay\/disorders or general population sample, <jats:italic>N<\/jats:italic>\u2009=\u20093454) were evaluated with the Child Behavior Checklist and Mullen Scales of Early Learning. We examined cannabis use during three time periods: peripregnancy, pregnancy, and only preconception. Peripregnancy cannabis exposure was reported for 6.0% of children with and 4.6% of children without ASD symptoms. Preconception\u2010only cannabis use (versus no use) was associated with more aggressive behavior, emotional reactivity, and sleep problems in children with ASD symptoms, but not in children without ASD symptoms. Cannabis use during pregnancy was associated with increased attention and sleep problems in children with ASD symptoms; these associations did not differ significantly by ASD symptoms. Peripregnancy cannabis use was not associated with child developmental abilities regardless of ASD symptoms. In summary, associations of peripregnancy cannabis use with some behavioral outcomes differed in children with and without ASD symptoms. With rising cannabis use among pregnant women, future studies that examine a range of developmental risks associated with timing and patterns of cannabis use prior to conception as well as during pregnancy could inform clinical guidance.<\/jats:p>","DOI":"10.1002\/aur.3284","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T18:03:51Z","timestamp":1733940231000},"page":"202-216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations of maternal peripregnancy cannabis use with behavioral and developmental outcomes in children with and without symptoms of autism spectrum disorder: Study to Explore Early Development"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6440-7817","authenticated-orcid":false,"given":"Carolyn","family":"DiGuiseppi","sequence":"first","affiliation":[{"name":"Colorado School of Public Health, Department of Epidemiology University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tessa","family":"Crume","sequence":"additional","affiliation":[{"name":"Colorado School of Public Health, Department of Epidemiology University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brady","family":"Holst","sequence":"additional","affiliation":[{"name":"Colorado School of Public Health, Department of Epidemiology University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaylynn","family":"Aiona","sequence":"additional","affiliation":[{"name":"Colorado School of Public Health, Department of Epidemiology University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Van Dyke","sequence":"additional","affiliation":[{"name":"Colorado School of Public Health, Department of Epidemiology University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7849-9428","authenticated-orcid":false,"given":"Lisa A.","family":"Croen","sequence":"additional","affiliation":[{"name":"Division of Research Kaiser Permanente Northern California  Oakland California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie L.","family":"Daniels","sequence":"additional","affiliation":[{"name":"Gillings School of Global Public Health University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Friedman","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Pediatrics University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine R.","family":"Sabourin","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Immunology and Microbiology University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura A.","family":"Schieve","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Wiggins","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gayle C.","family":"Windham","sequence":"additional","affiliation":[{"name":"California Department of Public Health, Environmental Health Investigations Branch  Richmond California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cordelia","family":"Robinson Rosenberg","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Pediatrics University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"University of Vermont, Research Center for Children, Youth, & Families","author":"Achenbach T. 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