{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:07:33Z","timestamp":1791587253733,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Angelman syndrome (AS) is a rare neurogenetic disorder. Previous studies indicate a high prevalence of autism spectrum disorder (ASD) with considerable variability. Little is known regarding the longitudinal trajectory of autistic traits. We aim to investigate autistic traits, the effect of age on these traits, and associated features in AS children. This (partly) longitudinal clinical record study at the ENCORE Expertise Center involved 107 AS children aged 2\u201318 with one (<jats:italic>N<\/jats:italic>\u2009=\u2009107), two (<jats:italic>N<\/jats:italic>\u2009=\u200949), or three (<jats:italic>N<\/jats:italic>\u2009=\u200914) measurements. Autistic traits and sensory processing issues were assessed using various instruments, and DSM classifications were used descriptively. Covariates were genotype, gender, and epilepsy. Results indicate a high prevalence of autistic traits and sensory processing issues. Children with the deletion genotype exhibited more autistic traits. Autism Diagnostic Observation Schedule (ADOS) classifications indicated higher rates of ASD compared to clinician DSM classifications. Autistic traits generally remained stable over time, except that ADOS scores significantly decreased for children with the <jats:italic>UBE3A<\/jats:italic> mutation genotype, and in the social affect domain for the entire group. In conclusion, incorporating the assessment of autistic traits and sensory processing into clinical practice for AS is important to inform adaptations of the environment to meet the child\u2019s needs. Additionally, clinicians and researchers should be mindful of the potential for overestimating ASD traits in AS when relying on the ADOS. ASD diagnosis in AS should integrate multiple diagnostic instruments, diverse hetero\u2010anamnestic sources, and multidisciplinary expert opinions.<\/jats:p>","DOI":"10.1002\/aur.70017","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T10:34:37Z","timestamp":1742726077000},"page":"870-880","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Age\u2010Related Trajectories of Autistic Traits in Children With Angelman Syndrome"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9274-6316","authenticated-orcid":false,"given":"Doesjka A.","family":"Hagenaar","sequence":"first","affiliation":[{"name":"ENCORE Expertise Centre for Neurodevelopmental Disorders Erasmus MC  Rotterdam the Netherlands"},{"name":"Department of Child\u2010 and Adolescent Psychiatry\/Psychology Erasmus MC  Rotterdam the Netherlands"},{"name":"Department of Pediatrics Erasmus MC  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine E.","family":"Mous","sequence":"additional","affiliation":[{"name":"ENCORE Expertise Centre for Neurodevelopmental Disorders Erasmus MC  Rotterdam the Netherlands"},{"name":"Department of Child\u2010 and Adolescent Psychiatry\/Psychology Erasmus MC  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3122-7713","authenticated-orcid":false,"given":"Leontine W.","family":"ten Hoopen","sequence":"additional","affiliation":[{"name":"ENCORE Expertise Centre for Neurodevelopmental Disorders Erasmus MC  Rotterdam the Netherlands"},{"name":"Department of Child\u2010 and Adolescent Psychiatry\/Psychology Erasmus MC  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9004-0836","authenticated-orcid":false,"given":"Andr\u00e9 B.","family":"Rietman","sequence":"additional","affiliation":[{"name":"ENCORE Expertise Centre for Neurodevelopmental Disorders Erasmus MC  Rotterdam the Netherlands"},{"name":"Department of Child\u2010 and Adolescent Psychiatry\/Psychology Erasmus MC  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil R.","family":"Hiralal","sequence":"additional","affiliation":[{"name":"ENCORE Expertise Centre for Neurodevelopmental Disorders Erasmus MC  Rotterdam the Netherlands"},{"name":"Department of Child\u2010 and Adolescent Psychiatry\/Psychology Erasmus MC  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen G. C. B.","family":"Bindels\u2010de Heus","sequence":"additional","affiliation":[{"name":"ENCORE Expertise Centre for Neurodevelopmental Disorders Erasmus MC  Rotterdam the Netherlands"},{"name":"Department of Pediatrics Erasmus MC  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter F. A.","family":"de Nijs","sequence":"additional","affiliation":[{"name":"ENCORE Expertise Centre for Neurodevelopmental Disorders Erasmus MC  Rotterdam the Netherlands"},{"name":"Department of Child\u2010 and Adolescent Psychiatry\/Psychology Erasmus MC  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa C.","family":"Mohr","sequence":"additional","affiliation":[{"name":"ENCORE Expertise Centre for Neurodevelopmental Disorders Erasmus MC  Rotterdam the Netherlands"},{"name":"Department of Child\u2010 and Adolescent Psychiatry\/Psychology Erasmus MC  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline J.","family":"Lens","sequence":"additional","affiliation":[{"name":"ENCORE Expertise Centre for Neurodevelopmental Disorders Erasmus MC  Rotterdam the Netherlands"},{"name":"Department of Child\u2010 and Adolescent Psychiatry\/Psychology Erasmus MC  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon H. J.","family":"Hillegers","sequence":"additional","affiliation":[{"name":"Department of Child\u2010 and Adolescent Psychiatry\/Psychology Erasmus MC  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriette A.","family":"Moll","sequence":"additional","affiliation":[{"name":"ENCORE Expertise Centre for Neurodevelopmental Disorders Erasmus MC  Rotterdam the Netherlands"},{"name":"Department of Pediatrics Erasmus MC  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Claire Y.","family":"de Wit","sequence":"additional","affiliation":[{"name":"ENCORE Expertise Centre for Neurodevelopmental Disorders Erasmus MC  Rotterdam the Netherlands"},{"name":"Department of Neurology and Pediatric Neurology Erasmus MC  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwen C.","family":"Dieleman","sequence":"additional","affiliation":[{"name":"ENCORE Expertise Centre for Neurodevelopmental Disorders Erasmus MC  Rotterdam the Netherlands"},{"name":"Department of Child\u2010 and Adolescent Psychiatry\/Psychology Erasmus MC  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229\u2010017\u20100185\u20101"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803\u2010019\u201004302\u20108"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61382"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10048\u2010007\u20100086\u20100"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19971030)16:20<2349::AID-SIM667>3.0.CO;2-E"},{"key":"e_1_2_10_12_1","volume-title":"Social Responsiveness Scale Second Edition (SRS\u20102): Manual","author":"Constantino J. N.","year":"2012"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0b013e3181ee408e"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803\u2010006\u20100280\u20101"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.13106"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010020\u20100858\u20106"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2014.10.003"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2022.104293"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)31129\u20102"},{"key":"e_1_2_10_20_1","volume-title":"Autism Diagnostic Observation Schedule (ADOS\u20102): Manual","author":"Lord C.","year":"2013"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.38.12.834"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.852208"},{"key":"e_1_2_10_23_1","volume-title":"Development and Validation of the Short Sensory Profile","author":"McIntosh D. N.","year":"1999"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36058"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2014.02.018"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102788.2009.01197.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1352\/1944\u20107558\u2010118.4.262"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2001.6617"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20107610.2007.01736.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rasd.2020.101671"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1934701"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20100004.2004.00362.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20107610.2011.02455.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803\u2010013\u20101879\u20107"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803\u2010020\u201004861\u20101"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2005.036913"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2013.01.028"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12989"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638280500190631"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/1362361304042720"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/10.1007\/s10803\u2010020\u201004526\u2010z"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2022.102230"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.5014\/ajot.60.4.472"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jir.12635"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31074"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37254"}],"container-title":["Autism Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aur.70017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T09:55:42Z","timestamp":1745402142000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/aur.70017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,21]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/aur.70017"],"URL":"https:\/\/doi.org\/10.1002\/aur.70017","archive":["Portico"],"relation":{},"ISSN":["1939-3792","1939-3806"],"issn-type":[{"value":"1939-3792","type":"print"},{"value":"1939-3806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,21]]},"assertion":[{"value":"2024-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}