{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:24:34Z","timestamp":1792106674133,"version":"4.4.0"},"reference-count":76,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["731827"],"award-info":[{"award-number":["731827"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Activation of the temporoparietal junction (TPJ) is reduced in autism spectrum disorder (ASD) during social cognitive tasks. Therefore, anodal transcranial direct current stimulation (tDCS) of the TPJ may enhance social cognitive abilities in autistic individuals. In a multicenter, randomized, sham\u2010controlled, double\u2010blind parallel\u2010group Phase\u2010IIa trial, we investigated feasibility, safety, and effect sizes of 10 sessions of anodal tDCS of the bilateral TPJ at 2\u2009mA as an add\u2010on to computer\u2010based social cognitive training in 10\u2010 to 17\u2010year\u2010old youth with autism. Feasibility of recruitment was low, with only 11% of screened individuals being randomized to tDCS (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200912) or sham (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200912). In contrast, retention in the study, data collection, intervention adherence, and technical feasibility were mostly excellent. No serious adverse events occurred, and stimulation was well tolerated. There were no differences in the prespecified primary outcome social responsiveness between sham and tDCS immediately after the intervention (standardized estimated effect size [ES]\u2009=\u20090.098; 95%\u2010confidence interval [95% CI] \u22121.043;1.240), but the sham group showed a trend for better social responsiveness at the 4\u2009week follow\u2010up (ES\u2009=\u20091.106; 95% CI \u22120.054; 2.270). Secondary outcomes including questionnaires and event\u2010related potentials showed improved compulsive behavior and quality of life by tDCS. High technical feasibility, participant retention, and safety highlight the potential of tDCS in autism and may inform future improvements in the feasibility of recruitment. The differential pattern of effect estimates indicates positive, but also potential negative effects of tDCS, which may vary due to tDCS stimulation parameters. The trial was prospectively registered in the German Clinical Trials Register (Deutsches Register f\u00fcr klinische Studien, DRKS, DRKS00014732).\n                  <\/jats:p>","DOI":"10.1002\/aur.70084","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T05:14:30Z","timestamp":1752729270000},"page":"1861-1876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Transcranial Direct Current Stimulation of the Temporoparietal Junction in Autism Spectrum Disorder: Results of a Phase\u2010IIa Randomized, Double\u2010Blind, Sham\u2010Controlled Feasibility Study"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5259-7174","authenticated-orcid":false,"given":"Christina","family":"Luckhardt","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt Goethe 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Child and Adolescent Psychiatry and Psychotherapy, Protestant Hospital Bethel EvKB  Bielefeld Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4364-6373","authenticated-orcid":false,"given":"Miguel","family":"Castelo\u2010Branco","sequence":"additional","affiliation":[{"name":"Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), ICNAS, Faculty of Medicine, Institute of Physiology University of Coimbra (UC)  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1423-3038","authenticated-orcid":false,"given":"Helena C.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), ICNAS, Faculty of Medicine, Institute of Physiology University of Coimbra (UC)  Coimbra 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Autism, CHRU Tours\/H\u00f4spital Bretonneau  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Salvador","sequence":"additional","affiliation":[{"name":"Neuroelectrics SLU  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Ruffini","sequence":"additional","affiliation":[{"name":"Neuroelectrics SLU  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafal","family":"Nowak","sequence":"additional","affiliation":[{"name":"Neuroelectrics SLU  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Siniatchkin","sequence":"additional","affiliation":[{"name":"Clinic of Child and Adolescent Psychiatry and Psychotherapy, Protestant Hospital Bethel EvKB  Bielefeld Germany"},{"name":"Clinic of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Aachen RWTH Aachen University  Aachen 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