{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:44:51Z","timestamp":1782960291341,"version":"3.54.5"},"reference-count":109,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Although there are as many as 40 preclinical models of the neurodevelopmental disorder Phelan McDermid syndrome (PMS, or 22q13.3 deletion syndrome), detailed phenotypic analyses to compare the effects of different pathogenic variants and inform treatment design are lacking. Here, we clarify behavioral traits (social, vocalization, repetitive and anxiety\u2010like behavior), developmental trajectories, and motor activity in addition to changes in brain structure and function in 10 widely available\n                    <jats:italic>Shank3<\/jats:italic>\n                    transgenic mouse models. Although behavioral deficits in\n                    <jats:italic>Shank3B<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    and\n                    <jats:italic>Shank3<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2206C\/\u2206C<\/jats:italic>\n                    <\/jats:sup>\n                    mice were most extensively reported, each model reviewed here displayed autism\u2010relevant behavioral traits. Most studies focused on assessing social, anxiety\u2010like, and repetitive behavior, whereas few studies examined changes in vocalization, developmental milestones, motor function, or aggressive behavior. We did not identify any studies of gut function in the ten selected\n                    <jats:italic>Shank3<\/jats:italic>\n                    models. Alterations in the gastrointestinal microbiome of Shank3\u2010deficient mice are associated with changes in bacterial abundance and composition, which may impact social behavior and gastrointestinal function. Studying preclinical models can provide critical insights into molecular pathways contributing to PMS. Further research is needed to determine how various genetic variations in Shank3 impact the brain, behavior, and potentially the gastrointestinal system.\n                  <\/jats:p>","DOI":"10.1002\/aur.70112","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:00:06Z","timestamp":1756375206000},"page":"1935-1964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Frank Assessment of\n                    <scp>SHANK<\/scp>\n                    : Impacts of Pathogenic Variations in\n                    <scp>SHANK3<\/scp>\n                    on Preclinical Models of Phelan\n                    <scp>McDermid<\/scp>\n                    Syndrome"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1263-7339","authenticated-orcid":false,"given":"Vic","family":"Lin","sequence":"first","affiliation":[{"name":"School of Health and Biomedical Sciences RMIT University  Bundoora Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha M.","family":"Matta","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences RMIT University  Bundoora Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia E.","family":"Dallman","sequence":"additional","affiliation":[{"name":"Department of Biology University of Miami  Coral Gables Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Hosie","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences RMIT University  Bundoora Victoria Australia"},{"name":"Department of Biomedical Engineering The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Moreau","sequence":"additional","affiliation":[{"name":"Human Genetics and Cognitive Functions, Institut Pasteur, UMR3571 CNRS, IUF, Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley E.","family":"Franks","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Anatomy and Physiology and Pharmacology La Trobe University  Bundoora Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bourgeron","sequence":"additional","affiliation":[{"name":"Human Genetics and Cognitive Functions, Institut Pasteur, UMR3571 CNRS, IUF, Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa L.","family":"Hill\u2010Yardin","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences RMIT University  Bundoora Victoria Australia"},{"name":"Department of Anatomy and Physiology The University of Melbourne  Parkville Victoria 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