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Investigating the functional activity of hippocampal subregions can provide valuable insights into their involvement in ASD\u2010related social and behavioral symptoms. This study analyzed hippocampal resting\u2010state functional connectivity (rsFC) in 507 male child participants from the ABIDE dataset (225 ASD, 282 typical controls) and its relation to clinical features. The hippocampus was subdivided into rostral and caudal subregions, and rsFC patterns were compared between groups. Significant group differences were observed in the left caudal, right rostral, and right caudal hippocampus, with enhanced connectivity to widespread cortical and subcortical regions, including visual, motor, parietal, and cerebellar networks. Machine learning using hippocampal rsFC achieved modest classification performance. Clinically, rsFC correlated with core ASD symptoms: social awareness was associated with right caudal connectivity to fusiform and temporal regions, while restricted and repetitive behaviors were linked to distinct rostral\u2013caudal patterns involving frontal, motor, and cerebellar areas. Age of onset showed positive correlations with rsFC across all subregions, with rostral hippocampus engaging socioemotional and motor control networks and caudal hippocampus connecting more strongly to visual and sensorimotor integration regions. These findings demonstrate subregional specificity of hippocampal connectivity in ASD, suggesting distinct anterior\u2013posterior contributions to symptom expression and developmental timing.<\/jats:p>","DOI":"10.1002\/aur.70124","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T08:38:44Z","timestamp":1759394324000},"page":"2231-2239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hippocampal Subregion Function and Its Clinical Correlations in Childhood Autism Spectrum Disorders"],"prefix":"10.1002","volume":"18","author":[{"given":"Hui\u2010Xian","family":"Li","sequence":"first","affiliation":[{"name":"Department of Clinical Research and Translational Medicine The Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Department of Radiology The Third Affiliated Hospital of Zhengzhou University  Zhengzhou 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