{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:45:13Z","timestamp":1790700313820,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["1863\u201024"],"award-info":[{"award-number":["1863\u201024"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Atypical infant head circumference (HC)\u2014including increased rates of macrocephaly and microcephaly\u2014has been linked to autism spectrum disorder (ASD). However, specific head growth trajectories associated with ASD remain poorly defined. This retrospective case\u2013control study aimed to delineate these trajectories and examine their relationship to height. The study sample included 262 children diagnosed with ASD and 560 matched controls. Growth measures at 1, 2, 4, 6, 9, and 12\u2009months of age were obtained from health clinics in southern Israel. The sample was classified into seven clusters based on HC patterns across these six time points, and associations with ASD were estimated using conditional logistic regression. Results demonstrated significant correlations between HC and height throughout the study period (Pearson correlation\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.44\u20130.55,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), with stronger correlations in ASD (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.50\u20130.67) compared to controls (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.32\u20130.50). Children with consistently small or large HC exhibited the highest ASD likelihood (adjusted odds ratio [aOR]\u2009=\u20092.95, 95% CI\u2009=\u20091.88\u20134.94; and aOR\u2009=\u20093.17, 95% CI\u2009=\u20091.92\u20135.01, respectively), with the most extreme percentiles (0\u20135th and 95th\u2013100th) showing the strongest associations (aOR\u2009=\u20099.53, 95% CI\u2009=\u20092.49\u201335.26; aOR\u2009=\u20096.51, 95% CI\u2009=\u20092.91\u201315.35, respectively). These associations were primarily driven by children with similar height trajectories (aOR\u2009=\u20097.71, 95% CI\u2009=\u20093.23\u201315.43; and aOR\u2009=\u20096.89, 95% CI\u2009=\u20092.99\u201313.26, respectively), indicating that atypical HC growth in ASD during infancy may reflect broader physiological growth dysregulation.\n                  <\/jats:p>","DOI":"10.1002\/aur.70172","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T07:15:10Z","timestamp":1767078910000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Head Growth Trajectories During the First Year of Life and Risk of Autism Spectrum Disorder"],"prefix":"10.1002","volume":"19","author":[{"given":"Rewaa","family":"Balaum","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Elbedour","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einav","family":"Alhozyel","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gal","family":"Meiri","sequence":"additional","affiliation":[{"name":"Preschool Psychiatric Unit Soroka University Medical Center  Beer\u2010Sheva Israel"},{"name":"Azrieli National Center for Autism and Neurodevelopment Research Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dikla","family":"Zigdon","sequence":"additional","affiliation":[{"name":"Preschool Psychiatric Unit Soroka University Medical Center  Beer\u2010Sheva Israel"},{"name":"Azrieli National Center for Autism and Neurodevelopment Research Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Analya","family":"Michaelovski","sequence":"additional","affiliation":[{"name":"Azrieli National Center for Autism and Neurodevelopment Research Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"},{"name":"Child Development Center Soroka University Medical Center  Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orly","family":"Kerub","sequence":"additional","affiliation":[{"name":"Ministry of Health  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1961-1461","authenticated-orcid":false,"given":"Idan","family":"Menashe","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"},{"name":"Azrieli National Center for Autism and Neurodevelopment Research Ben\u2010Gurion University of the Negev  Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229\u2010024\u201000586\u20105"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1319"},{"key":"e_1_2_9_5_1","volume-title":"The Health Care System in Israel","author":"Bin Nun G.","year":"2010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.2036"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2014.07.008"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rasd.2021.101845"},{"key":"e_1_2_9_9_1","unstructured":"Central Bureau of Statistics of Israel.2021.\u201cLive birth statistics. (Statistical abstract of Israel series; no.: 67)\u201d."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.106"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2024.1431693"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.09.101"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.3.337"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.2.245"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1362361320921037"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.07.016"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acap.2015.03.008"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2004.08.005"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031\u2010020\u201001671\u2010z"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229\u2010017\u20100129\u20109"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579406060202"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023036509476"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2023.03.015"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2010.09.004"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12264"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21369"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007\u20101172"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010021\u201002605\u20103"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019\u20103447"},{"key":"e_1_2_9_30_1","unstructured":"Israel Ministry of Health.2023.\u201cTipat Halav \u2013 Family Health Centers.\u201dAccessed February 12 2023 https:\/\/www.health.gov.il\/English\/Topics\/Pregnancy\/health_centers\/Pages\/family_health_centers.aspx."},{"key":"e_1_2_9_31_1","unstructured":"Israel Ministry of Health.2024.\u201cInfants Children and Adolescents: Growth Charts.\u201dAccessed December 25 2024 https:\/\/www.health.gov.il\/English\/Topics\/KidsAndMatures\/Pages\/curves.aspx."},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31465"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1643"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803\u2010017\u20103207\u20100"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807304005"},{"key":"e_1_2_9_36_1","unstructured":"National Institutes of Health.2024a.\u201cMacrocephaly.\u201dAccessed December 24 2024 https:\/\/elementsofmorphology.nih.gov\/index.cgi?tid=dd989bb153739761147ef05dc870b050."},{"key":"e_1_2_9_37_1","unstructured":"National Institutes of Health.2024b.\u201cMicrocephaly.\u201dAccessed December 24 2024 https:\/\/elementsofmorphology.nih.gov\/index.cgi?tid=0584d323b99dcd7001cc50e224947aca."},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1107560108"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2011.1413"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.2011"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.03.026"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2020.11.019"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac008"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2015.08.016"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.04.039"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010021\u201002815\u20109"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215\u20100366(18)30294\u20103"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31829e1d45"},{"key":"e_1_2_9_49_1","volume-title":"WHO Growth Charts","author":"U.S. Centers for Disease Control and Prevention","year":"2024"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.18772\/26180197.2024.v6n1a1"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2020.105224"}],"container-title":["Autism Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aur.70172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/aur.70172","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aur.70172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:48:14Z","timestamp":1772988494000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/aur.70172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/aur.70172"],"URL":"https:\/\/doi.org\/10.1002\/aur.70172","archive":["Portico"],"relation":{},"ISSN":["1939-3792","1939-3806"],"issn-type":[{"value":"1939-3792","type":"print"},{"value":"1939-3806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]},"assertion":[{"value":"2025-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70172"}}