{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T16:52:13Z","timestamp":1776963133011,"version":"3.51.4"},"reference-count":89,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/W011751\/1"],"award-info":[{"award-number":["MR\/W011751\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["Departments of Excellence 2018\u20102022"],"award-info":[{"award-number":["Departments of Excellence 2018\u20102022"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Autism Spectrum Disorder (ASD) is characterized by certain difficulties in emotion\u2010related processing. Recent research using electroencephalography (EEG) to measure somatosensory evoked potentials during emotion perception has shown reduced embodiment of emotional expressions in autistic compared to neurotypical individuals, independently from differences in visual processing. However, the underlying neural dynamics are not clear. In this study, we use Dynamic Causal Modeling (DCM) on EEG data to investigate whether reduced embodiment during emotion processing in ASD individuals is caused by changes in intrinsic connectivity within the somatosensory cortex, or by top\u2010down modulatory effects from higher\u2010order frontal areas. We constructed a model involving the primary and secondary right somatosensory cortex, the right supplementary motor area and the right inferior frontal gyrus, and tested effective connectivity during emotion or gender discrimination tasks in two groups of ASD and typically developing (TD) participants (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200938, male and female, 2 females). Our results reveal that task\u2010related differences in electrocortical activity between the emotion and gender tasks are causally explained by changes in intrinsic activity within the right primary somatosensory cortex (rS1) in both TD and ASD. Importantly, these intrinsic changes in rS1 are significantly different between TD and ASD groups and individual task\u2010related changes in rS1 significantly correlate with alexithymia traits. Our study provides novel evidence on the neural dynamics underlying difficulties in emotion processing in ASD individuals, highlighting that differential intrinsic activations of the rS1 are causally involved in such difficulties, and suggests that they are mediated by alexithymia.\n                  <\/jats:p>","DOI":"10.1002\/aur.70197","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:05:41Z","timestamp":1770973541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in Intrinsic Activity of the Primary Somatosensory Cortex Causally Explain Differences in Emotion Perception in Autism"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1222-2762","authenticated-orcid":false,"given":"Martina","family":"Fanghella","sequence":"first","affiliation":[{"name":"Psychology &amp; Neuroscience Department, School of Health and Medical Sciences City St George's, University of London  London UK"},{"name":"Cognition in Action (CIA) Unit, PHILAB, Department of Philosophy University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danai","family":"Dima","sequence":"additional","affiliation":[{"name":"Psychology &amp; Neuroscience Department, School of Health and Medical Sciences City St George's, University of London  London UK"},{"name":"Department of Neuroimaging Institute of Psychiatry, Psychology and Neuroscience, King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Pinotsis","sequence":"additional","affiliation":[{"name":"Psychology &amp; Neuroscience Department, School of Health and Medical Sciences City St George's, University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian B.","family":"Gaigg","sequence":"additional","affiliation":[{"name":"Psychology &amp; Neuroscience Department, School of Health and Medical Sciences City St George's, University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Calvo\u2010Merino","sequence":"additional","affiliation":[{"name":"Psychology &amp; Neuroscience Department, School of Health and Medical Sciences City St George's, University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Forster","sequence":"additional","affiliation":[{"name":"Psychology &amp; Neuroscience Department, School of Health and Medical Sciences City St George's, University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20\u201007\u201002683.2000"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-23-07678.1996"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2023.06.010"},{"key":"e_1_2_13_5_1","unstructured":"Ashburner J. G.Barnes C.Chen et\u00a0al.2014.SPM12 Manual.https:\/\/www.fil.ion.ucl.ac.uk\/spm\/doc\/manual.pdf."},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2010.0349"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1005653411471"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2009.0058"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht182"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.037"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.61"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803\u2010010\u20101024\u20109"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2017.07.048"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0935845100"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13415\u2010022\u201001015\u2010x"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv051"},{"key":"e_1_2_13_17_1","volume-title":"Social Responsiveness Scale. Second Edition (SRS\u20102)","author":"Constantino J. N.","year":"2012"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5636\u201011.2012"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2012.00175"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956797612463582"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1611"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.10.045"},{"key":"e_1_2_13_23_1","unstructured":"DCM for Evoked Responses\u2014SPM Documentation. n.d.DCM for Evoked Responses.https:\/\/www.fil.ion.ucl.ac.uk\/spm\/docs\/tutorials\/dcm\/dcm_erp\/."},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.12.086"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2400\u201011.2011"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1221880110"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0706\u201021.2022"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.06.011"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053\u20108119(03)00202\u20107"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2012.00113"},{"key":"e_1_2_13_31_1","first-page":"136236131666706","article-title":"The Psychophysiological Mechanisms of Alexithymia in Autism Spectrum Disorder","volume":"22","author":"Gaigg S. B.","year":"2016","journal-title":"Autism"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2020.01.017"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2005.01.012"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2015.12.003"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cognition.2004.01.005"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2011.0057"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013\u20104694(83)90135\u20109"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.02.021"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2012.09.008"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/1754073908100441"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.01.057"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41537\u2010025\u201000553\u2010w"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010023\u201002559\u20103"},{"key":"e_1_2_13_44_1","unstructured":"JASP Team.2024.JASP (Version 0.19.3). (n.d.). [Computer Software]."},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.11.037"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.2466\/11.IT.3.1"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20108986.1980.tb00190.x"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2009.10.006"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2833"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2024.105877"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.02.046"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0090\u201015.2016"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229\u2010025\u201000644\u20106"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2023.06.010"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2025.121650"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.12639"},{"key":"e_1_2_13_57_1","volume-title":"The Karolinska Directed Emotional Faces (KDEF)","author":"Lundqvist D.","year":"1998"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2024.120604"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229\u2010019\u20100294\u20100"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nst084"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208034"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.08.006"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1136930"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803\u2010019\u201004279\u20104"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1177\/1362361320987950"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000709"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2920"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhy065"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1450\u201008.2008"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2004.03794.x"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23035"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.08.065"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep12432"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2019.00351"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2017.01.001"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2020.04.002"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0106\u201013.2014"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2016.03.021"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2010.05.035"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1080\/17470910701577020"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1177\/1745691617708630"},{"key":"e_1_2_13_82_1","unstructured":"SPM12 Software\u2014Statistical Parametric Mapping. n.d.SPM12 Software\u2014Statistical Parametric Mapping.https:\/\/www.fil.ion.ucl.ac.uk\/spm\/software\/spm12\/."},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.03.025"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20103999(02)00601\u20103"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118486"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1080\/17470910701376878"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsaa110"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2006.06.003"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsn007"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"}],"container-title":["Autism Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aur.70197","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/aur.70197","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aur.70197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T16:26:54Z","timestamp":1776961614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/aur.70197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,13]]},"references-count":89,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/aur.70197"],"URL":"https:\/\/doi.org\/10.1002\/aur.70197","archive":["Portico"],"relation":{},"ISSN":["1939-3792","1939-3806"],"issn-type":[{"value":"1939-3792","type":"print"},{"value":"1939-3806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,13]]},"assertion":[{"value":"2025-06-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70197"}}