{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:01:54Z","timestamp":1790085714663,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401498"],"award-info":[{"award-number":["82401498"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sleep disturbances are common in children with autism spectrum disorder (ASD). However, the sleep pattern changes including rapid eye movement (REM) sleep for ASD in pediatric populations remain unknown. Using polysomnography (PSG) data from the National Children's Hospital (NCH) Sleep Databank, we identified 193 children with ASD and matched them with 193 Non\u2010ASD controls. We found children with ASD showed reduced REM sleep proportion (17.8%\u2009\u00b1\u20096.4% vs. 19.1%\u2009\u00b1\u20097.0%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.049) and duration (71.5 [49.5\u201391.0] min vs. 81.5 [52.5\u201398.0] min;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.036), prolonged REM latency (134.5 [94.0\u2013181.5] min vs. 116.0 [82.0\u2013157.0] min;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.009), and increased 1st REM duration (13.0 [7.0\u201319.0] min vs. 10.5 [6.0\u201316.5] min;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.024) compared with Non\u2010ASD peers. They also showed higher 1st REM proportion (18.8 [11.0\u201331.3] vs. 15.7 [8.3\u201325.4];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003), particularly in children aged 3\u20135\u2009years and 6\u20138\u2009years. Using these REM features, the XGBoost machine learning model was achieved to be the best predictive performance. SHAP analysis further showed that decreased REM sleep duration, increased 1st REM proportion or duration, and prolonged REM latency were discriminative features for children with ASD. These findings suggest that REM sleep abnormalities are common in young patients with ASD but its contribution to the disease's severity and\/or development needs to be explored further.\n                  <\/jats:p>","DOI":"10.1002\/aur.70222","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T09:55:58Z","timestamp":1774259758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>REM<\/scp>\n                    Sleep Abnormalities in Children With Autism Spectrum Disorder"],"prefix":"10.1002","volume":"19","author":[{"given":"Jiasen","family":"Ma","sequence":"first","affiliation":[{"name":"Perioperative and Systems Medicine Laboratory, Department of Rehabilitation and Department of Anesthesiology, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescent's Health and Diseases  Hangzhou China"},{"name":"Department of Anesthesiology Affiliated Hospital of Hangzhou Normal University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Affiliated Hospital of Hangzhou Normal University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Perioperative and Systems Medicine Laboratory, Department of Rehabilitation and Department of Anesthesiology, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescent's Health and Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueping","family":"Che","sequence":"additional","affiliation":[{"name":"Perioperative and Systems Medicine Laboratory, Department of Rehabilitation and Department of Anesthesiology, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescent's Health and Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Li","sequence":"additional","affiliation":[{"name":"Perioperative and Systems Medicine Laboratory, Department of Rehabilitation and Department of Anesthesiology, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescent's Health and Diseases  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1235-0537","authenticated-orcid":false,"given":"Daqing","family":"Ma","sequence":"additional","affiliation":[{"name":"Perioperative and Systems Medicine Laboratory, Department of Rehabilitation and Department of Anesthesiology, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescent's Health and Diseases  Hangzhou China"},{"name":"Division of Anesthetics, Pain Medicine &amp; Intensive Care, Department of Surgery and Cancer, Faculty of Medicine Imperial College London, Chelsea and Westminster Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4599-2317","authenticated-orcid":false,"given":"Jinpiao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Perioperative and Systems Medicine Laboratory, Department of Rehabilitation and Department of Anesthesiology, Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescent's Health and Diseases  Hangzhou 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