{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:05:18Z","timestamp":1784300718377,"version":"3.55.0"},"reference-count":79,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002332","name":"Semmelweis Egyetem","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","award":["BO\/00277\/23\/5"],"award-info":[{"award-number":["BO\/00277\/23\/5"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","award":["NAP2022\u2010I\u20103\/2022"],"award-info":[{"award-number":["NAP2022\u2010I\u20103\/2022"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011903","name":"Richter Gedeon Talentum Alap\u00edtv\u00e1ny","doi-asserted-by":"publisher","award":["DKOP\u201023"],"award-info":[{"award-number":["DKOP\u201023"]}],"id":[{"id":"10.13039\/501100011903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031691","name":"\u00c1llatorvostudom\u00e1nyi Egyetem","doi-asserted-by":"publisher","award":["SRF\u2010002"],"award-info":[{"award-number":["SRF\u2010002"]}],"id":[{"id":"10.13039\/100031691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022B1515130007"],"award-info":[{"award-number":["2022B1515130007"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A0505050121"],"award-info":[{"award-number":["2023A0505050121"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Variants in the CNTNAP2 gene, encoding the cell adhesion molecule CASPR2, have been identified as genetic risk factors for autism spectrum disorder (ASD). However, the mechanisms through which CNTNAP2 dysfunction alters circuit function remain unknown. Interneurons, as key regulators of excitatory\u2013inhibitory balance, represent a candidate source of vulnerability. In this study, we quantified calretinin\u2010positive (CR+) and parvalbumin\u2010positive (PV+) interneuron density in the caudoputamen (CP) and somatosensory cortex (SSC) of\n                    <jats:italic>Cntnap2<\/jats:italic>\n                    knockout (KO) and wild\u2010type (WT) mice and assessed their relationship with social behavior.\n                    <jats:italic>Cntnap2<\/jats:italic>\n                    KO mice exhibited significantly lower CR+ interneuron density in both brain regions, whereas no significant difference was observed in the PV+ density.\n                    <jats:italic>Cntnap2<\/jats:italic>\n                    KO females showed altered behavior in the social novelty preference test compared to WT females.\n                    <jats:italic>Cntnap2<\/jats:italic>\n                    KO animals also displayed elevated \u201cmoving away\u201d responses, a social withdrawal phenotype. Correlation analyses revealed that within the KO group, higher striatal CR+ density was associated with a greater frequency and duration of \u201cmoving away.\u201d CR+ density in the SSC did not correlate with this behavioral phenotype. The results suggest that striatal CR+ interneurons may modulate the persistence and intensity of social withdrawal behavior. In conclusion, our findings reveal region\u2010specific alterations in CR+ interneuron density in\n                    <jats:italic>Cntnap2<\/jats:italic>\n                    KO mice and uncover a previously unrecognized link between\n                    <jats:italic>Cntnap2<\/jats:italic>\n                    function, striatal interneuron organization and social withdrawal behavior. The results highlight CR+ interneurons as potential contributors to altered basal ganglia function in ASD and underscore the need for circuit\u2010level analyses of genetically defined risk models.\n                  <\/jats:p>","DOI":"10.1002\/aur.70286","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T09:09:47Z","timestamp":1780736987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lower Striatal and Cortical Calretinin Interneuron Density Associated With Altered Social Behavior in\n                    <i>Cntnap2<\/i>\n                    Knockout Mice"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9699-254X","authenticated-orcid":false,"given":"Krisztina","family":"S\u00e1f\u00e1r","sequence":"first","affiliation":[{"name":"Department of Anatomy, Histology and Embryology, Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivien","family":"Szendi","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Systems Neurobiology, Department of Physiology and Neurobiology E\u00f6tv\u00f6s Lor\u00e1nd University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4399-6424","authenticated-orcid":false,"given":"Paulina","family":"Hoppa","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology and Embryology, Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology and Embryology, Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanni \u00c1.","family":"Seres","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Systems Neurobiology, Department of Physiology and Neurobiology E\u00f6tv\u00f6s Lor\u00e1nd University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szilvia","family":"Bart\u00f3k","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Systems Neurobiology, Department of Physiology and Neurobiology E\u00f6tv\u00f6s Lor\u00e1nd University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Teadora","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology and Embryology, Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[{"name":"JNU\u2010HKUST Joint Laboratory for Neuroscience and Innovative Drug Research College of Pharmacy, Jinan University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0397-2991","authenticated-orcid":false,"given":"\u00c1rp\u00e1d","family":"Dobolyi","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology and Embryology, Faculty of Medicine Semmelweis University  Budapest Hungary"},{"name":"Laboratory of Molecular and Systems Neurobiology, Department of Physiology and Neurobiology E\u00f6tv\u00f6s Lor\u00e1nd University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0710-602X","authenticated-orcid":false,"given":"Gina","family":"Puska","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Systems Neurobiology, Department of Physiology and Neurobiology E\u00f6tv\u00f6s Lor\u00e1nd University  Budapest Hungary"},{"name":"Department of Zoology University of Veterinary Medicine Budapest  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3318-9789","authenticated-orcid":false,"given":"Istv\u00e1n","family":"Adorj\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology and Embryology, Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706128104"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx131"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.7573"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.109747"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2007.09.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.9.1.357"},{"key":"e_1_2_9_8_1","unstructured":"\u201cAllen Institute for Brain Science Allen Mouse Brain Atlas.\u201d2004.https:\/\/mouse.brain\u2010map.org\/."},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","unstructured":"\u201cAmerican Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders Fifth Edition Text Revision.\u201dAmerican Psychiatric Association 2022.","DOI":"10.1176\/appi.books.9780890425787"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1383728"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw349"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2007.09.015"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2007.09.017"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1554\u201007.2007"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201017204\u20105"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010933404324"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsgos.2021.11.005"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsgos.2024.100413"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(00)24024-7"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.11.031"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.7554\/elife.100162.3"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201024358\u20104"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhab233"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13428\u2010022\u201001901\u20109"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.577525"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2021.107990"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.23\u201028\u201009320.2003"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13060891"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24373"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/bs15081073"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u20107091\u20109211\u20105_4"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2147780"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010neuro\u2010061010\u2010113641"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2020.00032"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16\u201010\u201003397.1996"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw021"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4332.The"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101506\u20107"},{"key":"e_1_2_9_39_1","unstructured":"Larsen E. S.Spring\u2010Pearson C.Printzis G.Nagendra andS.Banerjee\u2010Basu.2025. \u201cSFARI GENE Q4\/2025 REPORT MindSpec Inc. October \u2013 December.\u201dhttps:\/\/gene.sfari.org."},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2016.00150"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00262"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100404.2009.01234.x"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010019\u20100531\u2010z"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/children9020272"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010024\u201002754\u20108"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20612"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201004358\u20106"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.08.040"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010257"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81049-1"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-19-07568.2001"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200305018"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.21307\/ane\u20102019\u2010031"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010021\u201001142\u2010w"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-183X.2003.00037.x"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00385"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2015.08.016"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2019.109658"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.19.10415"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2014.00003"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11689\u2010018\u20109237\u2010x"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx341"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aah6733"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1835"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010019\u20100426\u20100"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052773"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041\u2010021\u201000775\u2010w"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2018.00091"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23042294"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2012.00056"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.06.033"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav8130"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx248"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.382987"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803\u2010020\u201004615\u2010z"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201039434\u20105"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22229"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10360"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.2696"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041\u2010025\u201001233\u20107"}],"container-title":["Autism Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aur.70286","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/aur.70286","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aur.70286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:24:51Z","timestamp":1784298291000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/aur.70286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,6]]},"references-count":79,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/aur.70286"],"URL":"https:\/\/doi.org\/10.1002\/aur.70286","archive":["Portico"],"relation":{},"ISSN":["1939-3792","1939-3806"],"issn-type":[{"value":"1939-3792","type":"print"},{"value":"1939-3806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,6]]},"assertion":[{"value":"2025-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70286"}}