{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:30:51Z","timestamp":1793154651945,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Individuals with autism spectrum disorder (ASD) often experience premature mortality and co\u2010occurring psychiatric conditions, for which antidepressants are commonly prescribed. However, the long\u2010term safety of antidepressant use in this population remains unclear. Using data from the Taiwan National Health Insurance Research Database, we emulated a target trial to examine the association between antidepressant use and mortality among individuals with ASD aged 6\u201364\u2009years diagnosed between 2000 and 2016. A three\u2010step approach of cloning, censoring, and inverse probability of censoring weighting was applied to address immortal\u2010time bias. Participants were followed for up to 5\u2009years to assess all\u2010cause, suicide, and accidental\u2010cause mortality. Among 33,939 eligible individuals, 779 initiated antidepressants within a 3\u2010month grace period. Antidepressant use was not associated with all\u2010cause or suicide mortality overall. However, it was significantly associated with reduced accidental\u2010cause mortality at both 2 (HR\u2009=\u20090.15; 95% CI, 0.04\u20130.53) and 5\u2009years (HR\u2009=\u20090.05; 95% CI, 0.01\u20130.20). Subgroup analysis revealed increased 2\u2010year all\u2010cause mortality among youths (HR\u2009=\u20094.40; 95% CI, 1.10\u201317.58) but significantly decreased 5\u2010year accidental mortality in the age groups of 6\u201315\u2009years (HR\u2009=\u20090.06; 95% CI, 0.01\u20130.41) and over 24\u2009years (HR\u2009=\u20090.06; 95% CI, 0.01\u20130.42). Additionally, decreased 5\u2010year suicide mortality was observed in the 16\u201324 age group (HR\u2009=\u20090.17; 95% CI, 0.05\u20130.61). While antidepressant use may reduce accidental mortality in individuals with ASD, age\u2010specific risks warrant careful consideration and monitoring, particularly among younger populations.<\/jats:p>","DOI":"10.1002\/aur.70302","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T05:55:23Z","timestamp":1786600523000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mortality and Antidepressants Among Individuals With Autism Spectrum Disorder: A Population\u2010Based Cohort Study"],"prefix":"10.1002","volume":"19","author":[{"given":"Vincent Chin\u2010Hung","family":"Chen","sequence":"first","affiliation":[{"name":"Departments of Psychiatry and Health Information and Epidemiology Laboratory Chang Gung Memorial Hospital, Chiayi Branch  Chiayi Taiwan"},{"name":"School of Medicine, Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hsin","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Medicine MacKay Medical University  New Taipei City Taiwan"},{"name":"Section of Psychiatry MacKay Memorial Hospital  Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Lung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Healthcare Administration, College of Medical and Health Science Asia University  Taichung Taiwan"},{"name":"Department of Medical Research China Medical University Hospital, China Medical University  Taichung Taiwan"},{"name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory National Innovation Platform for Industry\u2010Education Integration in Vaccine Research, School of Public Health, Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Dewey","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai\u2010Hsin","family":"Hung","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Health Information and Epidemiology Laboratory Chang Gung Memorial Hospital, Chiayi Branch  Chiayi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010I","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Medicine MacKay Medical University  New Taipei City Taiwan"},{"name":"Section of Psychiatry MacKay Memorial Hospital  Taipei City 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