{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:37:10Z","timestamp":1786631830813,"version":"build-2736575974"},"reference-count":105,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["5R01HD108222\u201003"],"award-info":[{"award-number":["5R01HD108222\u201003"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fragile X syndrome (FXS), the most common inherited cause of intellectual disability and autism spectrum disorder, causes significant language and cognitive impairments. Statistical learning refers to the ability to extract patterns from sensory input through mere exposure and plays a central role in language acquisition. Surprisingly, statistical learning in FXS has not been explored. Given that children with FXS typically follow a delayed developmental trajectory for language, we hypothesized that they would show impaired statistical learning. To test this hypothesis, we used an EEG measure of neural entrainment to index statistical learning of hidden trisyllabic words within a continuous speech stream in children with FXS (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200917) and in typically developing controls (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200931). Children with FXS showed significantly reduced neural entrainment to words compared to controls, particularly in the superior temporal gyrus and transverse temporal gyrus (primary auditory cortex), providing evidence of statistical learning impairment. Notably, syllable\u2010level entrainment was preserved or even enhanced in FXS, indicating that word\u2010level deficits cannot be attributed to general auditory processing impairments. In addition, while typically developing controls showed an increase in word\u2010level entrainment over the course of learning, children with FXS failed to show a similar increase over time. Taken together, this pattern of results demonstrates that children with FXS can process rapid, lower\u2010order acoustic structure but struggle to integrate these syllables into longer, chunk\u2010like word representations. Overall, these findings suggest that statistical learning is impaired in FXS and also suggest neural entrainment to statistical structure as a potential therapeutic target.\n                  <\/jats:p>","DOI":"10.1002\/aur.70312","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T01:45:07Z","timestamp":1783907107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aberrant Neural Entrainment to Word\u2010Level Speech Patterns in Fragile X Syndrome: Evidence for a Statistical Learning Deficit"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6879-4666","authenticated-orcid":false,"given":"Laura J.","family":"Batterink","sequence":"first","affiliation":[{"name":"Department of Psychology; Western Centre for Brain and Mind, Western Institute for Neuroscience University of Western Ontario  London Ontario 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