{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:50:31Z","timestamp":1792162231885,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007108","name":"George Washington University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K01MH129622"],"award-info":[{"award-number":["K01MH129622"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Among older adults in the general population, medications with anticholinergic (AC) effects are associated with declines in cognitive functioning and with dementia and Alzheimer's disease. Autistic people have high rates of co\u2010occurring medical conditions and polypharmacy across the lifespan; thus, they may be at particularly high risk of exposure to AC medications and their negative impacts on cognitive functioning, including earlier in adulthood. Consistent with this, a single study has shown AC medication use is prevalent among autistic adults without co\u2010occurring intellectual disability and is associated with self\u2010reported concurrent memory problems and declines in cognition. No study has examined AC medications and their associations with cognition among autistic adults with higher support needs. We therefore characterized AC medication use and its associations with caregiver\u2010rated memory problems and changes in cognition and behavior that have been linked with cognitive decline. Caregivers of autistic adults (18\u201368\u2009years; Mean ~31\u2009years) recruited via Simons Powering Autism Research's (SPARK) Research Match service reported medication use (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009512), memory complaints (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009467), and a screener that probes behavior\/cognitive changes (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009466) that are associated with cognitive decline among persons with an intellectual disability. The majority (66.41%) of autistic adults were taking at least one AC medication and 31% were taking clinically\u2010meaningful levels of these medications. After controlling for age and birth sex, greater potency of AC medications was associated with both caregiver\u2010reported memory challenges and behavioral\/cognitive changes associated with cognitive decline. Understanding AC medication use and its potential impacts on cognition among autistic adults with higher support needs is crucial.\n                  <\/jats:p>","DOI":"10.1002\/aur.70342","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:32:49Z","timestamp":1786613569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of Anticholinergic Medication Use and Its Associations With Everyday Memory Problems and Cognitive Decline in Autistic Adults With Higher Support Needs"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3614-616X","authenticated-orcid":false,"given":"Goldie A.","family":"McQuaid","sequence":"first","affiliation":[{"name":"George Mason University  George Mason Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6663-0713","authenticated-orcid":false,"given":"Nancy Raitano","family":"Lee","sequence":"additional","affiliation":[{"name":"Drexel University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0329-5054","authenticated-orcid":false,"given":"Gregory L.","family":"Wallace","sequence":"additional","affiliation":[{"name":"The George Washington University  Washington, DC 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