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At 24 weeks after surgery, electrophysiological assessment, behavioral analysis, and histological examination were conducted to evaluate the outcomes of peripheral nerve repair. The nerve conduit allowed nerve reconstruction between two stumps and reinnervation of the target gastrocnemius muscle. For two groups of rats repaired respectively by the nerve conduit and autologous nerve graft, the density of regenerated axons was 3.55 \u00b1 0.51 and 3.91 \u00b1 0.14 (<jats:italic>P<\/jats:italic> = 0.712), and the cross\u2010sectional area of target muscles was 1,159.68 \u00b1 305.85 and 1,307.06 \u00b1 301.25 (<jats:italic>P<\/jats:italic> = 0.922), respectively, without significant differences between the two groups. Our data suggest the feasibility of using chitosan\u2010based, NGF\u2010loaded nerve conduits for peripheral nerve repair.<\/jats:p>","DOI":"10.1002\/bab.1031","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T14:01:07Z","timestamp":1347026467000},"page":"388-394","source":"Crossref","is-referenced-by-count":37,"title":["Repairing rat sciatic nerve injury by a nerve\u2010growth\u2010factor\u2010loaded, chitosan\u2010based nerve conduit"],"prefix":"10.1002","volume":"59","author":[{"given":"Hongkui","family":"Wang","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Neuroregeneration Nantong University  Nantong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Joint Surgery &amp; Sport Medicine The First Affiliated Hospital of General Hospital of PLA The Orthopedic Institute of C.P.L.A. 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