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Sprague\u2013Dawley rats were given CCl<jats:sub>4<\/jats:sub> twice per week for 8 weeks to induce liver fibrosis. Then, they were treated with HBOA, TC\u20102, and TC\u20103 daily for 4 weeks, respectively. The serum indicators including total protein (TP), albumin (Alb), globulin, hyaluronic acid (HA), and laminin (LN) were measured by commercial kits. The messenger ribonucleic acid expression of adiponectin, peroxisome proliferator\u2010activated receptor\u2010\u03b3 (PPAR\u2010\u03b3), tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), interleukin\u20106 (IL\u20106), transforming growth factor\u2010\u03b2<jats:sub>1<\/jats:sub> (TGF\u2010\u03b2<jats:sub>1<\/jats:sub>) and Toll\u2010like receptor 4 (TLR<jats:sub>4<\/jats:sub>) was determined by reverse\u2010transcriptase \u2010PCR. The proteins of adiponectin, TGF\u2010\u03b2<jats:sub>1<\/jats:sub>, \u03b1\u2010smooth muscle actin (\u03b1\u2010SMA), and TLR<jats:sub>4<\/jats:sub> were also detected by the immunohistochemical assay. The results showed that HBOA, TC\u20102, and TC\u20103 significantly attenuated the fibrotic degree induced by CCl<jats:sub>4<\/jats:sub> as evidenced by higher levels of TP, Alb, adiponectin, and PPAR\u2010\u03b3, which in turn decreased the proliferation of hepatic stellate cells. Moreover, those drugs markedly decreased the levels of HA, LN, TNF\u2010\u03b1, IL\u20106, TGF\u2010\u03b2<jats:sub>1<\/jats:sub>, \u03b1\u2010SMA, and TLR<jats:sub>4<\/jats:sub>. Our study indicates that HBOA, TC\u20102, and TC\u20103 have beneficial effects against liver fibrosis, and the mechanisms may be related to the inhibition of inflammatory response.<\/jats:p>","DOI":"10.1002\/bab.1292","type":"journal-article","created":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T09:38:42Z","timestamp":1410341922000},"page":"537-546","source":"Crossref","is-referenced-by-count":19,"title":["The protective effects of <i>Acanthus ilicifolius<\/i> alkaloid A and its derivatives on pro\u2010 and anti\u2010inflammatory cytokines in rats with hepatic fibrosis"],"prefix":"10.1002","volume":"62","author":[{"given":"Kyi Kyi","family":"Wai","sequence":"first","affiliation":[{"name":"Department of Pharmacology Guangxi Medical University  Nanning People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinge","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Guangxi Medical University  Nanning People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Guangxi Medical University  Nanning People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Guangxi Medical University  Nanning People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhong","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Guangxi Medical University  Nanning People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Guangxi Medical University  Nanning People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Guangxi Medical University  Nanning People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huahui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry and Physical Chemistry Guangxi Medical University  Nanning People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Guangxi Medical University  Nanning People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.07.024"},{"key":"e_1_2_8_3_1","first-page":"1501","volume":"30","author":"Xie L.","year":"2005","journal-title":"China J. 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