{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:08:33Z","timestamp":1761293313695},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biotech and App Biochem"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The potency of conventional antivenom (AV) conjugated to soy protein nanoparticles (NPs) (C\u2010AV) was compared with the free AV in neutralizing the systemic toxicity of <jats:italic>Naja naja<\/jats:italic> venom. The effective dose (ED<jats:sub>50<\/jats:sub>) of AV and C\u2010AV to neutralize the venom\u2010induced toxicity in mice was found to be 19.89 and 9.50\u00a0mg, respectively. The histopathological examination of heart, liver, and kidney indicated that the systemic toxicity induced by the venom was effectively neutralized by lower concentrations of C\u2010AV than compared with AV. In addition, C\u2010AV was found to be more effective in neutralizing the edema forming activity of <jats:italic>N. naja<\/jats:italic> venom compared with the AV. Thus, the results of this study indicate that the potency of commercially available AV could be improved by conjugating it to soy protein NPs.<\/jats:p>","DOI":"10.1002\/bab.1428","type":"journal-article","created":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T10:35:47Z","timestamp":1440412547000},"page":"827-833","source":"Crossref","is-referenced-by-count":2,"title":["Pre\u2010clinical assessment of the effectiveness of modified polyvalent antivenom in the neutralization of <i>Naja naja<\/i> venom toxicity"],"prefix":"10.1002","volume":"63","author":[{"given":"Renu","family":"Kadali","sequence":"first","affiliation":[{"name":"School of Bio Sciences and Technology Vellore Institute of Technology  Vellore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gopi","family":"Kadiyala","sequence":"additional","affiliation":[{"name":"School of Bio Sciences and Technology Vellore Institute of Technology  Vellore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayaraman","family":"Gurunathan","sequence":"additional","affiliation":[{"name":"School of Bio Sciences and Technology Vellore Institute of Technology  Vellore India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-4959(01)00473-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(97)00160-8"},{"key":"e_1_2_7_4_1","first-page":"635","volume":"103","author":"Whitaker R.","year":"2012","journal-title":"Curr. 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