{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T19:41:53Z","timestamp":1783712513216,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T00:00:00Z","timestamp":1517961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Social Development Major Scientific and Technological Projects in Xiaoshan District of Hangzhou city","award":["2014304"],"award-info":[{"award-number":["2014304"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biotech and App Biochem"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osteoarthritis (OA) is a common bone and joint disease with a wild range of risk factors, which is associated with endoplasmic reticulum (ER) stress. The aim of our study was to discuss the possible mechanism of ER stress associated with OA <jats:italic>in vivo<\/jats:italic> and explore novel therapeutic method against OA. OA\u2010induced damages in cartilage tissues were evaluated by HE, Safranin O\/fast green, and TUNEL staining. The inflammatory factors concentration and the expression of FAP, MMP2, MMP9, Bax, Bcl\u20102, CHOP, and GRP78 were evaluated by ELISA, real\u2010time PCR, and Western blot analyses. As results, 4\u2010phenylbutyric acid (4\u2010PBA)\u2010treated OA cartilage tissues presented alleviated tissue damage with less apoptotic cells and cytokine production in comparison with advanced\u2010OA tissues. Downregulation of Bax\/Bcl\u20102, CHOP, GRP78, inflammatory factors, and reactive oxygen species generation, and the increase of MMP level detected after 4\u2010PBA treatment indicated an inhibitory effect of 4\u2010PBA on cell apoptosis, inflammatory response, and ER stress in OA. In conclusion, we indicate that ER stress causes cell apoptosis and inflammatory response, resulting in the tissue damage within OA. At the same time, 4\u2010PBA exhibited protective effect on cartilage cells against OA through the inhibition of ER stress.<\/jats:p>","DOI":"10.1002\/bab.1642","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T03:52:40Z","timestamp":1515729160000},"page":"540-546","source":"Crossref","is-referenced-by-count":30,"title":["4\u2010Phenylbutyric acid presents therapeutic effect on osteoarthritis via inhibiting cell apoptosis and inflammatory response induced by endoplasmic reticulum stress"],"prefix":"10.1002","volume":"65","author":[{"given":"Yang\u2010hua","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Orthopedics Xiaoshan Traditional Chinese Medical Hospital  Hangzhou 311201 Zhejiang People's Republic of 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