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The aim of this study is to inhibit amyloidogenesis by using preparatory polymeric nanomicelles as therapeutic agents and also as nanocarriers for curcumin to target A\u03b2 fibrils through the glycation method of bovine serum albumin (BSA) in the presence of phosphate\u2010buffered saline. Polymeric nanomicelles were prepared from phosphatidylethanolamine\u2010distearoyl methoxypolyethylene glycol conjugates in the presence and absence of curcumin and then the morphological and structural characteristics of the nanomicelles were characterized in detail. Following the preparation of unloaded and curcumin\u2010loaded nanomicelles with the desired size and properties, their effects on BSA glycation\/fibrillation process were investigated. The samples were analyzed by thioflavin T (ThT) fluorescence and advanced glycation end (AGE) products autofluorescence measurements. The results showed that ThT fluorescence related to the formation of \u03b2\u2010sheets and AGE autofluorescence (associated with AGE production) decreased in the presence of curcumin\u2010loaded nanomicelles more than other samples. In conclusion, the promising effect of curcumin\u2010loaded nanomicelles on inhibition of amyloidogenesis through glycation process due to curcumin release and thus their ability to prevent the formation and accumulation of amyloid fibrils and so to suppress the Alzheimer's disease progression has been proven and can go for further investigations.<\/jats:p>","DOI":"10.1002\/bab.1751","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T06:25:17Z","timestamp":1555482317000},"page":"537-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Preparation and characterization of curcumin\u2010loaded polymeric nanomicelles to interference with amyloidogenesis through glycation method"],"prefix":"10.1002","volume":"66","author":[{"given":"Zeinab","family":"Mirzaie","sequence":"first","affiliation":[{"name":"Faculty of Biomedical Engineering Amirkabir University of Technology  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Meybod University  Meybod Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soheila Salahshour","family":"Kordestani","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical Engineering Amirkabir University of Technology  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehran Habibi","family":"Rezaei","sequence":"additional","affiliation":[{"name":"School of Biology, College of Science University of Tehran  Tehran Iran"},{"name":"Nano\u2010Biomedicine Center of Excellence, Nanoscience and Nanotechnology Research Center University of Tehran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0232-352X","authenticated-orcid":false,"given":"Masoud","family":"Mozafari","sequence":"additional","affiliation":[{"name":"Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC)  Tehran Iran"},{"name":"Cellular and Molecular Research Center Iran University of Medical Sciences  Tehran Iran"},{"name":"Department of Tissue Engineering &amp; Regenerative Medicine Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","unstructured":"Alzheimer's Association.(2015).Alzheimer's disease facts and figures.11(3) 332.","DOI":"10.1016\/j.jalz.2015.02.003"},{"key":"e_1_2_8_3_1","unstructured":"Alzheimer's Association(2009).Alzheimers Demen.5(3) 234\u2013270."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.09.063"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1249\/JSR.0000000000000332"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.02.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.05.1769"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(00)00029-6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.12.015"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2011.03.008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.06.035"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.18433\/jpps30117"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b06201"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.01.039"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.04.044"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00222348.2014.984578"},{"issue":"3","key":"e_1_2_8_17_1","first-page":"124","volume":"28","author":"Masoud M.","year":"2014","journal-title":"Trends. 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