{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:32:14Z","timestamp":1786977134257,"version":"build-2736575974"},"reference-count":95,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biotech and App Biochem"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Homocysteine [HSCH\n                    <jats:sub>2<\/jats:sub>\n                    CH\n                    <jats:sub>2<\/jats:sub>\n                    CH(NH\n                    <jats:sub>2<\/jats:sub>\n                    )COOH] (Hcy) is a sulfur\u2010containing amino acid of 135.18 Da of molecular weight, generated during conversion of methionine to cysteine. If there is a higher accumulation of Hcy in the blood, that is usually above 15\u00a0\u00b5mol\/L, it leads to a condition referred to as hyperhomocysteinemia. A meta\u2010analysis of observational study suggested an elevated concentration of Hcy in blood, which is termed as the risk factors leading to ischemic heart disease and stroke. Further experimental studies stated that Hcy can lead to an increase in the proliferation of vascular smooth muscle cells and functional impairment of endothelial cells. The analyses confirmed some of the predictors for Hcy presence, such as serum\u00a0uric acid (UA), systolic blood pressure, and hematocrit. However, angiotensin\u2010converting enzyme inhibitors angiotensin\u2010converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) alone are inadequate for controlling UA and creatinine level, although the addition of folic acid may be beneficial in hypertensive patients who are known to have a high prevalence of elevated Hcy. We hypothesized that combination therapy with an ARB (olmesartan) and folic acid is a promising treatment for lowering the UA and creatinine level in hyperhomocysteinemia\u2010associated hypertension.\n                  <\/jats:p>","DOI":"10.1002\/bab.1799","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T09:03:17Z","timestamp":1563354197000},"page":"715-719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Combinational effect of angiotensin receptor blocker and folic acid therapy on uric acid and creatinine level in hyperhomocysteinemia\u2010associated hypertension"],"prefix":"10.1002","volume":"66","author":[{"given":"Yogendra","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences Mahatma Gandhi College of Pharmaceutical Sciences  Sitapura Jaipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya Paul","family":"Samuel","sequence":"additional","affiliation":[{"name":"Department of Anatomy RAK College of Medicine RAK Medical and Health Sciences, University  Ras Al Khaimah UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Dahiya","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences School of Pharmacy University of Puerto Rico, Medical Sciences Campus  San Juan Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7941-0229","authenticated-orcid":false,"given":"Gaurav","family":"Gupta","sequence":"additional","affiliation":[{"name":"School of Pharmacy Suresh Gyan Vihar University  Jagatpura Jaipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Gillhotra","sequence":"additional","affiliation":[{"name":"School of Pharmacy Suresh Gyan Vihar University  Jagatpura Jaipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag","family":"Mishra","sequence":"additional","affiliation":[{"name":"School of Pharmacy Suresh Gyan Vihar University  Jagatpura Jaipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahaveer","family":"Singh","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Jaipur National University  Jagatpura Jaipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagaraja","family":"SreeHarsha","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Clinical Pharmacy King Faisal University  Al\u2010Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva Kumar","family":"Gubbiyappa","sequence":"additional","affiliation":[{"name":"School of Pharmacy GITAM University  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murtaza M.","family":"Tambuwala","sequence":"additional","affiliation":[{"name":"School of Pharmacy &amp; Pharmaceutical Sciences Ulster University  Coleraine Northern Ireland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh Kumar","family":"Chellappan","sequence":"additional","affiliation":[{"name":"Department of Life Sciences International Medical University  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Dua","sequence":"additional","affiliation":[{"name":"Discipline of Pharmacy Graduate School of Health University of Technology Sydney  Sydney NSW Australia"},{"name":"Priority Research Centre for Healthy Lungs School of Biomedical Sciences and Pharmacy The University of Newcastle  Callaghan Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0021-9258(18)76074-2","volume":"99","author":"Lewis W.","year":"1932","journal-title":"J. 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