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The present study aimed to identify liposoluble molecules produced by <jats:italic>Ganoderma lipsiense<\/jats:italic> grown in red rice medium using solid\u2010state fermentation (SSF) techniques, and to investigate the antigiardial and antibacterial activities potential of extracts <jats:italic>in vitro<\/jats:italic>. Eighteen fatty acids and derivatives were identified by gas chromatograph\u2010mass spectrometry (GC\u2010MS) analysis in <jats:italic>G. lipsense<\/jats:italic> extract. Qualitative (Fourier transform infrared spectroscopy and nuclear magnetic resonance) characterizations identified the steroid ergosta\u20106,22\u2010diene\u20103\u03b2,5\u03b1,8\u03b1\u2010triol in purified hexane subfraction (<jats:italic>HEXsf<\/jats:italic>) <jats:italic>F19<\/jats:italic> isolated from hexane fraction (<jats:italic>HEXf<\/jats:italic>) of crude extract (<jats:italic>CE<\/jats:italic>). Ergosta\u20106,22\u2010diene\u20103\u03b2,5\u03b1,8\u03b1\u2010triol exhibited significant inhibitory activity against <jats:italic>Giardia duodenalis<\/jats:italic> throphozoites (93.6%) in <jats:italic>in vitro<\/jats:italic> assays. <jats:italic>CE<\/jats:italic> and <jats:italic>HEXf<\/jats:italic> inhibited 95.38% and 92.74% of the <jats:italic>G. duodenalis<\/jats:italic> throphozoites in 100\u00a0\u00b5g mL<jats:sup>\u22121<\/jats:sup>, whereas <jats:italic>CE<\/jats:italic> and their fractions dichloromethane (<jats:italic>DCMf<\/jats:italic>) and ethyl acetate (<jats:italic>EAf<\/jats:italic>) showed antibacterial activities against <jats:italic>Pseudomonas aeruginosa<\/jats:italic> and <jats:italic>Staphylococcus aureus<\/jats:italic> at 500\u00a0\u00b5g mL<jats:sup>\u22121<\/jats:sup>. Importantly, some liposoluble compounds produced and identified in <jats:italic>G. lipsiense<\/jats:italic> are unpublished for this species. This is first report for the production of ergosta\u20106,22\u2010diene\u20103\u03b2,5\u03b1,8\u03b1\u2010triol by <jats:italic>G. lipsiense<\/jats:italic> and its antiparasitic activity.<\/jats:p>","DOI":"10.1002\/bab.1851","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T11:14:40Z","timestamp":1573470880000},"page":"180-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Liposoluble compounds from <i>Ganoderma lipsiense<\/i> grown on solid red rice medium with antiparasitic and antibacterial properties"],"prefix":"10.1002","volume":"67","author":[{"given":"Tania Maria","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Chemical and Food Engineering Federal University of Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Lenzi","sequence":"additional","affiliation":[{"name":"Graduate Program in Environmental Engineering Regional University of Blumenau  Blumenau Santa Catarina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Jeriani","family":"Paganelli","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Regional University of Blumenau  Blumenau Santa Catarina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herc\u00edlio Higino da Silva","family":"Filho","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences Regional University of Blumenau  Blumenau Santa Catarina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele Debiasi","family":"Alberton","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Regional University of Blumenau  Blumenau Santa Catarina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena Benathar Ballod","family":"Tavares","sequence":"additional","affiliation":[{"name":"Graduate Program in Environmental Engineering Regional University of Blumenau  Blumenau Santa Catarina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7544-5045","authenticated-orcid":false,"given":"D\u00e9bora","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Chemical and Food Engineering Federal University of Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-018-2083-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40011-015-0574-1"},{"key":"e_1_2_7_4_1","unstructured":"Mycobank. 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