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Cellular function assays revealed that GTPs inhibited melanoma cell proliferation, migration, invasion, epithelial\u2010mesenchymal transition (EMT), and promoted apoptosis in vitro. Circ_MITF expression was elevated in melanoma tissues and cells but was decreased by GTPs in cells. Functional experiments indicated circ_MITF overexpression reversed the anticancer effects of GTPs on melanoma cells. Then the underlying mechanism analysis suggested that circ_MITF served as a sponge for miR\u201030e\u20103p to upregulate the level of <jats:italic>HDAC2<\/jats:italic>. MiR\u201030e\u20103p reexpression attenuated the regulatory effects of circ_MITF on GTPs\u2010treated melanoma cells. Silencing of miR\u201030e\u20103p promoted the malignant phenotypes in GTPs\u2010treated melanoma cells, which were reversed by <jats:italic>HDAC2<\/jats:italic> knockdown. Preclinically, administration of GTPs suppressed the expression of downstream target genes and repressed tumorigenesis of xenografts in nude mice. In all, GTPs suppressed melanoma progression by regulating circ_MITF\/miR\u201030e\u20103p\/<jats:italic>HDAC2<\/jats:italic> axis, providing a potential therapeutic strategy for human malignant melanoma intervention.<\/jats:p>","DOI":"10.1002\/bab.2153","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T04:49:12Z","timestamp":1617338952000},"page":"808-821","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Green tea polyphenols inhibit malignant melanoma progression via regulating circ_MITF\/miR\u201030e\u20103p\/HDAC2 axis"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4094-7808","authenticated-orcid":false,"given":"Kejia","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Dermatology Changzhou Hospital of Traditional Chinese Medicine  Changzhou 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