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Pretreatment with leaf extract and nuciferine (200 and 20 mg\/kg body weight, respectively) against MI induced by isoproterenol (85 mg\/kg body weight) significantly decreased heart weight; levels of cardiac markers such as lactate dehydrogenase and creatine kinase\u2010MB were similar to those in controls. The treatment significantly increased the content of endogenous antioxidants and decreased lipid peroxidation in all treated groups. Treated groups showed a significant reduction in heartbeats per minute as compared with the MI\u2010induced positive control. The MI\u2010induced group showed pathological implications such as tachycardia, left atrial enlargement, and anterolateral ST\u2010elevated MI, which were absent in treated groups. Histology confirmed that the leaf extract and nuciferine prevented structural abnormality and inflammation in heart and liver tissues of treated groups. On\n                    <jats:italic>in silico<\/jats:italic>\n                    analysis, nuciferine showed stronger binding interaction with both \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    and \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    adrenergic receptors than isoproterenol. Hence, the leaf extract of\n                    <jats:italic>N. nucifera<\/jats:italic>\n                    and nuciferine could be used as plant\u2010based cardioprotective agents.\n                  <\/jats:p>","DOI":"10.1002\/bab.2194","type":"journal-article","created":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T20:38:17Z","timestamp":1621197497000},"page":"1176-1189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Nuciferine from\n                    <i>Nelumbo nucifera<\/i>\n                    Gaertn. attenuates isoproterenol\u2010induced myocardial infarction in Wistar rats"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4038-6692","authenticated-orcid":false,"given":"Rajendran","family":"HarishKumar","sequence":"first","affiliation":[{"name":"Department of Biotechnology, VIT School of Agricultural Innovations and Advanced Learning (VAIAL), SBST Vellore Institute of Technology  Vellore Tamil Nadu 632014 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5292-0122","authenticated-orcid":false,"given":"Chinnadurai Immanuel","family":"Selvaraj","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, VIT School of Agricultural Innovations and Advanced Learning (VAIAL), SBST Vellore Institute of Technology  Vellore Tamil Nadu 632014 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Taber's cyclopedic medical dictionary","author":"Venes D.","year":"2017"},{"key":"e_1_2_9_3_1","first-page":"15","article-title":"Comparison between type\u20102 and type\u20101 myocardial infarction: clinical features, treatment strategies and outcomes","volume":"13","author":"L\u00f3pez\u2010Cuenca A","year":"2016","journal-title":"J Geriatr Cardiol."},{"key":"e_1_2_9_4_1","first-page":"309","volume":"82","author":"McCarthy CP","year":"2018","journal-title":"Type 2 myocardial infarction\u2015an evolving entity. 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