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PON1 is known for preventing atherosclerosis through lipid\u2010modifying features, as well as which has decisive actions of antiapoptosis, anti\u2010inflammatory, antithrombosis, and antiadhesion antioxidant activity properties. Thus, reducing the enzyme levels in hyperthyroidism, chronic renal failure, glaucoma, diabetes mellitus, and cardiovascular diseases is a significant risk. This study was tested some ophthalmic drugs used to treat the diseases, such as glaucoma and allergic conjunctivitis, mentioned above, travoprost, latanoprost, ketotifen, emedastine, and olopatadine, for their inhibition activities against PON1. These drugs displayed the potent inhibition effect with IC<jats:sub>50<\/jats:sub> values ranging between 14.95 \u00b1 0.15 and 299.60 \u00b1 4.07 \u03bcM and <jats:italic>K<\/jats:italic><jats:sub>I<\/jats:sub> constants ranging from 9.71 \u00b1 2.63 to 261.50 \u00b1 59.98 \u03bcM. Besides, the molecular docking analyses of the competitive inhibitors, travoprost, emedastine, and olopatadine, were performed to understand the binding interactions on the enzyme's binding site. According to both in vitro and in silico analysis results, travoprost had the most potent effect on PON1 enzyme activity.<\/jats:p>","DOI":"10.1002\/bab.2284","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T07:10:09Z","timestamp":1637133009000},"page":"2273-2283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Ophthalmic drugs: in vitro paraoxonase 1 inhibition and molecular docking studies"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2350-184X","authenticated-orcid":false,"given":"B\u00fc\u015fra","family":"\u00c7al\u0131\u015fkan","sequence":"first","affiliation":[{"name":"Department of Opthalmology Ka\u011f\u0131zman State Hospital  Ka\u011f\u0131zman Kars 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