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Upon fractionation, the ethyl acetate fraction with 46.9\u00a0\u00b1\u00a02.17 mg GAE\/g DW was found as a highest phenolic content. The PRF successfully loaded into nanoliposome structure with a nanometer in size (193.2 nm) and spherical shape and homogeneous dispersion. The gallic acid, salicylic acid, caffeic acid, cinnamic acid, catechin, ellagic acid, and ferulic acid are bioactive phenolics present in the nanoliposome\u2010loaded PRF; however, the main bioactive compounds are cinnamic acid (911\u00a0\u03bcg\/g DW) and ellagic acid (826\u00a0\u03bcg\/g DW). The infection caused by <jats:italic>E. coil<\/jats:italic> impaired the weight gain and food intake, liver function, morpho structural characteristics of jejunum, upregulated the expression of inflammatory genes (Cox2, iNOS), downregulation of antioxidant\u2010related genes (SOD, GPX), and increased the ileal population of <jats:italic>E. coil<\/jats:italic>. The addition of nonencapsulated PRF and nanoliposome\u2010encapsulated PRF at the concentration of 10\u00a0mg TPC\/kg BW\/day improved these parameters although the nanoliposome\u2010encapsulated PRF revealed more potential as compared with the nonencapsulated PRF in improving the health parameters in mice. The higher health\u2010promoting activity of nanoliposome\u2010encapsulated PRF could be associated with its enhanced intestinal absorption, bioavailability, bioaccessibility, and bioactivity. Consequently, the nanoliposome\u2010encapsulated PRF could be considered as a promising phytobiotic against <jats:italic>E. coil<\/jats:italic> infection in mice.<\/jats:p>","DOI":"10.1002\/bab.2303","type":"journal-article","created":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T13:20:40Z","timestamp":1639228840000},"page":"2540-2549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<i>Rheum ribes<\/i> extract\u2010loaded nanoliposome as a novel phytogenic\u00a0antibiotic alternative in mice challenged by <i>Escherichia coli<\/i> (O157:H7)"],"prefix":"10.1002","volume":"69","author":[{"given":"Mona Taghipoor","family":"Shamansoori","sequence":"first","affiliation":[{"name":"Department of Biology, Mashhad Branch Islamic Azad University  Mashhad 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