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In this study, an efficient method was developed for the synthesis of N\u2032\u2010alkyl benzohydrazides by hydrazine insertion catalyzed by lipase. Under the optimal conditions (Morita\u2013Baylis\u2013Hillman ketone [1\u00a0mmol], phenylhydrazine [1.3\u00a0mmol],\n                    <jats:italic>N,N<\/jats:italic>\n                    \u2010dimethylformamide [2\u00a0ml], lipase [20 mg], room temperature, 12\u00a0h), satisfactory yields (71\u201397%) and substrate tolerance were obtained when porcine pancreatic lipase was used as biocatalyst. These findings imply the great potential for the lipase\u2010catalyzed synthesis of N\u2032\u2010alkyl benzohydrazides and extend the utilization of lipase in organic chemistry.\n                  <\/jats:p>","DOI":"10.1002\/bab.2335","type":"journal-article","created":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T23:08:56Z","timestamp":1647212936000},"page":"130-136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lipase\u2010catalyzed hydrazine insertion for the synthesis of N\u2032\u2010alkyl benzohydrazides"],"prefix":"10.1002","volume":"70","author":[{"given":"Yue","family":"Yu","sequence":"first","affiliation":[{"name":"Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengxi","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory 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