{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:02:02Z","timestamp":1785445322818,"version":"3.56.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biotech and App Biochem"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Nanoparticles (NPs) have gained more attention as drug delivery systems. Folic acid (FA)\u2010chitosan (CS) conjugates, because of their biodegradability, low toxicity, and better stability, offer a pharmaceutical drug delivery tool. The aim of this work was to fabricate CuS NPs modified by CS followed by grafting FA as a nanocarrier for the delivery of cytarabine (CYT) as an anticancer drug. In this work, CuS NPs modified by CS and FA were successfully synthesized. The structural properties of the nanocarrier were characterized by using scanning electron microscopy, Fourier transform infrared, X\u2010ray diffraction, thermogravimetric analysis, and Brunauer\u2013Emmett\u2013Teller. The adsorption mechanism of CYT by adsorption isotherms, kinetics, and thermodynamics was deliberated and modeled. The in vitro CYT release behavior for the nanocarrier was 99% and 61% at pH 5.6 and 7.4, respectively. The adsorption behavior of CYT by CuS NP\n                    <jats:sub>s<\/jats:sub>\n                    \u2013CS\u2013FA was well explored by pseudo\u2013second\u2010order kinetic and Langmuir isotherm models by the coefficient of determination (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    &gt; 0.99). Thermodynamic results showed that the uptake of CYT by CuS NPs\u2010CS\u2010FA was endothermic and spontaneous. The experimental results showed that CYT\/CuS NP\n                    <jats:sub>s<\/jats:sub>\n                    \u2010CS\u2010FA can be proposed as an efficient nanocarrier for the targeted delivery of anticancer drugs.\n                  <\/jats:p>","DOI":"10.1002\/bab.2355","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T15:11:26Z","timestamp":1652454686000},"page":"330-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["In vitro evaluation of copper sulfide nanoparticles decorated with folic acid\/chitosan as a novel pH\u2010sensitive nanocarrier for the efficient controlled targeted delivery of cytarabine as an anticancer drug"],"prefix":"10.1002","volume":"70","author":[{"given":"Roya","family":"Hamrang","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, Science and Research Branch Islamic Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1961-9298","authenticated-orcid":false,"given":"Elham","family":"Moniri","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Varamin\u2010Pishva Branch Islamic Azad University  Varamin Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Heydarinasab","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Science and Research Branch Islamic Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raheleh","family":"Safaeijavan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, Varamin\u2010Pishva Branch Islamic Azad University  Varamin Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom9120773"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111239"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-020-00668-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2016.01.054"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.07.032"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2019.01.006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S596"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201601081"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120849"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2019.01.014"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.10.032"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2017.10.004"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.12.013"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2020.108369"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00589"},{"key":"e_1_2_7_17_1","first-page":"17","article-title":"Investigation of in vitro and in vivo atifungal property of biologically synthesized copper nanoparticles (CuNP) against rhizoctonia solani a phytopathogen of soyaabean (Glycine max, L. 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