{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:01:55Z","timestamp":1785445315041,"version":"3.56.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biotech and App Biochem"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The current study explored the hepatoprotective and immunomodulatory effects of Linalool (Lin) against carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    )\u2010induced toxicity in mice. Four study groups (\n                    <jats:italic>n<\/jats:italic>\n                    = 8 each) were used: (1) a negative control group and (2) a toxicity control group (single dose of CCl\n                    <jats:sub>4<\/jats:sub>\n                    administered on day 14 as 1 mL\/kg of CCL\n                    <jats:sub>4<\/jats:sub>\n                    in 1% olive oil). Intraperitoneally (i.p.)), and two experimental groups where mice were treated with either (3) Lin (25 mg\/kg b.w., orally, daily for 15 days) or (4) pretreated with Lin (25 mg\/kg b.w., orally, daily for 14 days) and intoxicated with CCl\n                    <jats:sub>4<\/jats:sub>\n                    (1 mL\/kg of CCL\n                    <jats:sub>4<\/jats:sub>\n                    in 1% olive oil. i.p.) on day 14. The levels of the anti\u2010inflammatory cytokine interleukin 10 (IL\u201010), the proinflammatory cytokines TNF\u2010\u03b1, IL\u20106, and TGF\u20101\u03b2, and the histopathology of the liver were assessed. According to our findings, IL\u201010 concentrations were significantly increased in Lin\u2010treated groups, while other cytokine levels were marked by a considerable decrease in the toxicity model group (CCl\n                    <jats:sub>4<\/jats:sub>\n                    \u2010treated group). Histopathological examinations of liver tissues showed that the Lin\u2010treated groups had an almost normal structure. The current findings showed that Lin could inhibit CCl\n                    <jats:sub>4<\/jats:sub>\n                    \u2010induced liver injury in mice, which warrants further investigation of Lin as a potential protective and therapeutic agent against hepatotoxicity.\n                  <\/jats:p>","DOI":"10.1002\/bab.2371","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T07:54:18Z","timestamp":1656057258000},"page":"469-477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Immunomodulatory effect of Linalool (Lin) against CCl\n                    <sub>4<\/sub>\n                    \u2010induced hepatotoxicity and oxidative damage in rats"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3837-5532","authenticated-orcid":false,"given":"Anis Ben","family":"Hsouna","sequence":"first","affiliation":[{"name":"Department of Life Sciences Faculty of Sciences of Gafsa  Gafsa Tunisia"},{"name":"Laboratory of Biotechnology and Plant Improvement Centre of Biotechnology of Sfax  Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9243-1056","authenticated-orcid":false,"given":"Carmen","family":"Sadaka","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Infection Control, and Employee Health The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4909-4154","authenticated-orcid":false,"given":"Marc El","family":"Beyrouthy","sequence":"additional","affiliation":[{"name":"Holy Spirit University of Kaslik  Jounieh Mount Lebanon Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2966-4551","authenticated-orcid":false,"given":"Mbarka","family":"Hfaiedh","sequence":"additional","affiliation":[{"name":"Research Unit of Active Biomolecules Valorisation, Higher Institute of Applied Biology of Medicine University of Gabes  Medenine Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1457-254X","authenticated-orcid":false,"given":"Wissal","family":"Dhifi","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Valorisation of Bio\u2010GeoRessources, Higher Institute of Biotechnology of Sidi Thabet University of Manouba, BiotechPole of Sidi Thabet  Ariana Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8435-381X","authenticated-orcid":false,"given":"Faical","family":"Brini","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Plant Improvement Centre of Biotechnology of Sfax  Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0559-0911","authenticated-orcid":false,"given":"Rania Ben","family":"Saad","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Plant Improvement Centre of Biotechnology of Sfax  Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8123-4743","authenticated-orcid":false,"given":"Wissem","family":"Mnif","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Sciences and Arts in Balgarn University of Bisha  Bisha Saudi Arabia"},{"name":"ISBST, BVBGR\u2010LR11ES31 University of Manouba, Biotechpole Sidi Thabet  Ariana 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