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In this study, polyethylene glycol\u2010modified albumin nanoparticles were synthesized by desolvation method; after loading of naringenin (NRG), folic acid (FA) binding to the surface of nanoparticles was performed (BSA\u2013PEG\u2013FA\u2013NG\u2013NPs). The extent of NRG trapping and FA binding was assessed indirectly using UV absorption methods. The physicochemical properties of BSA\u2013PEG\u2013FA\u2013NG\u2013NPs were investigated by DLS, SEM electron microscopy, and FTIR methods, after which their effects were evaluated on the apoptosis mechanism via MTT, flow cytometry, and qPCR methods. The BSA\u2013PEG\u2013FA\u2013NG\u2013NPs with spherical morphology had dimensions of 205\u00a0nm with zeta\u2010potential of 20.61\u00a0mV and dispersion index of 0.36. The NRG encapsulation was 84% and the FA binding was 75%. Anticancer effects of BSA\u2013PEG\u2013FA\u2013NG\u2013NPs were confirmed based on inhibiting breast cancer cells (IC50: 922\u00a0\u00b5g\/ml), cell cycle arrest (SubG1 phase), and induction of apoptosis (upregulation of Caspase 3, 8, and 9).<\/jats:p>","DOI":"10.1002\/bab.2399","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T04:59:49Z","timestamp":1662353989000},"page":"790-797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Fabrication of bovine serum albumin\u2010polyethylene glycol nanoparticle conjugated\u2010folic acid loaded\u2010naringenin as an efficient carrier biomacromolecule for suppression of cancer cells"],"prefix":"10.1002","volume":"70","author":[{"given":"Kimia","family":"Firouzabadi","sequence":"first","affiliation":[{"name":"Department of Biology, Mashhad Branch Islamic Azad University  Mashhad 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