{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:38:51Z","timestamp":1792463931198,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biotech and App Biochem"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Gestational diabetes mellitus (GDM) is a common pregnant disorder that needs careful medical attention.\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetyl\u2010L\u2010cysteine (NAC) is a well\u2010recognized antioxidant to treat oxidative stress\u2010induced diseases. Although its role in GDM has been reported, the mechanism remains largely unknown. Therefore, our current study further explored its protective role against GDM. An 8\u2010week\u2010old, db\/+, female mice were injected with a single dose of 100\u00a0mg\/kg streptozotocin (STZ) to induce diabetes. Pregnant mice were randomly treated with 1200\u00a0mg\/kg NAC or water daily. On gestational day 19, oral glucose tolerance test was performed, and visceral fat tissue and blood samples were collected. After delivery, litter size and weight were recorded. NAC could effectively improve GDM\u2010induced glucose intolerance, hyperlipidemia, activated inflammation, and oxidative stress in GDM mice. Moreover, NAC reduced the litter size and weight of GDM mice. NAC also activated the nuclear factor\u2010erythroid factor 2\u2010related factor 2 (Nrf2)\/heme oxygenase\u20101 (HO\u20101) signaling pathway in the liver of GDM mice. NAC effectively ameliorated GDM symptoms and the reproductive outcome of GDM mice through inhibiting oxidative stress, inflammation, and hyperlipidemia. Therefore, NAC might serve as a potential candidate drug against GDM.\n                  <\/jats:p>","DOI":"10.1002\/bab.2426","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:30:10Z","timestamp":1671064210000},"page":"1128-1136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<i>N<\/i>\n                    \u2010acetyl\u2010L\u2010cysteine ameliorates gestational diabetes mellitus by inhibiting oxidative stress"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1174-0998","authenticated-orcid":false,"given":"Pei","family":"Wang","sequence":"first","affiliation":[{"name":"Obstetrical Department 1 Cangzhou Central Hospital  Cangzhou Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hehong","family":"Ma","sequence":"additional","affiliation":[{"name":"Obstetrical Department 1 Cangzhou Central Hospital  Cangzhou 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