{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T10:27:13Z","timestamp":1752229633484,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biotech and App Biochem"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study intended to explore the preventive effects of <jats:italic>Pueraria lobata<\/jats:italic> leaves against doxorubicin (DOX)\u2010induced myocardial infarction (MI) in Wistar rats. The rats were separated into four groups, with each group containing six rats. Group I control rats; group II received DOX\u2010alone in six equivalent injections for 2 weeks; group III received DOX as abovementioned with <jats:italic>P. lobata<\/jats:italic> oral administration for 2 weeks; group IV received <jats:italic>P. lobata<\/jats:italic> alone for 2 weeks. At the end of the experiment, postcervical dislocation and MI induced by DOX were determined on the basis of the variations in the animal body and heart weight and further instabilities in cardiac marker enzymes aspartate transaminase, lactate dehydrogenase, creatine kinase, creatine kinase\u2010myoglobin binding, and cardiac troponin I in the serum. At the same time, for group III animals, which were exposed to <jats:italic>P. lobata<\/jats:italic>, all the above\u2010denoted marker levels were maintained. Levels of some crucial heart\u2010binding proteins like heart fatty acid binding protein, monocyte chemoattractant protein\u20101, and transforming growth factor beta were elevated in DOX\u2010alone treated rats. Additionally, group III animals treated with <jats:italic>P. lobata<\/jats:italic> showed some preventive downregulated expressions of these binding proteins. Histopathological observations also revealed the preventive effect of <jats:italic>P. lobata<\/jats:italic>. Ultimately proteins tangled in the phosphoinositide 3\u2010kinase\/protein kinase B pathway were studied by Western blot. <jats:italic>P. lobata<\/jats:italic> treatment downregulated the inflammatory markers. The findings suggest that <jats:italic>P. lobata<\/jats:italic> exhibits cardioprotective effect on MI.<\/jats:p>","DOI":"10.1002\/bab.2462","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T07:11:44Z","timestamp":1679555504000},"page":"1641-1651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Protective effect of <i>Pueraria lobata<\/i> leaves on doxorubicin\u2010induced myocardial infarction in experimental Wistar rats"],"prefix":"10.1002","volume":"70","author":[{"given":"Lei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiovascular The First People's Hospital of Xianyang  Xianyang Shaanxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2436-8956","authenticated-orcid":false,"given":"Annamalai","family":"Vijayalakshmi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Rabiammal Ahamed Maideen College for Women  Thiruvarur Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13368"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.09.028"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5724973"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-017-2061-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/681367"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10054-0060"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep28399"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2012.03.006"},{"key":"e_1_2_8_10_1","first-page":"1","article-title":"Medical values, antimicrobial, and anti\u2010fungal activities of Polyalthia genus","volume":"11","author":"Mustafa M","year":"2019","journal-title":"Int J Pharm Res"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.09.039"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.670479"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21564"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2016.04.049"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000265166"},{"key":"e_1_2_8_16_1","first-page":"865","article-title":"Anthracycline cardiomyopathy monitored by morphologic changes","volume":"62","author":"Billingham ME","year":"1978","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007094214460"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.10.3585"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2010.09.002"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/606183"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.07.037"},{"key":"e_1_2_8_22_1","first-page":"2514","article-title":"Prevention of KBrO3\u2010induced cardiotoxicity by Sonchus asper in rat","volume":"5","author":"Khan MR","year":"2011","journal-title":"J Med Plants Res"},{"key":"e_1_2_8_23_1","first-page":"4049","article-title":"Cardioprotective effects of Curcuma longa L. extracts against doxorubicin\u2010induced cardiotoxicity in rats","volume":"5","author":"El\u2010Sayed EM","year":"2011","journal-title":"J Med Plants Res"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/08977198809000251"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3923\/ijp.2017.1098.1102"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35726-4"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40816-019-0146-7"}],"container-title":["Biotechnology and Applied Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bab.2462","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bab.2462","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T03:02:27Z","timestamp":1697079747000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/bab.2462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,28]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/bab.2462"],"URL":"https:\/\/doi.org\/10.1002\/bab.2462","archive":["Portico"],"relation":{},"ISSN":["0885-4513","1470-8744"],"issn-type":[{"type":"print","value":"0885-4513"},{"type":"electronic","value":"1470-8744"}],"subject":[],"published":{"date-parts":[[2023,3,28]]},"assertion":[{"value":"2022-07-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}