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In humans and experimental animals, bromelain, the primary active ingredient isolated from pineapple stems, has several positive effects, including anti\u2010tumor growth, anticoagulation, and anti\u2010inflammation. Hence, the purpose of this study was to determine the possible protective impact of bromelain on some metabolic enzymes (paraoxonase\u20101, glutathione <jats:italic>S<\/jats:italic>\u2010transferase, glutathione reductase, sorbitol dehydrogenase [SDH], aldose reductase [AR], butyrylcholinesterase [BChE], and acetylcholinesterase [AChE]), activity in the heart, kidney, and liver of rats with tyloxapol\u2010induced hyperlipidemia. Rats were divided into three groups: control group, HL\u2010control group (tyloxapol 400\u00a0mg\/kg, i.p. administered group), and HL+bromelain (group receiving bromelain 250\u00a0mg\/kg\/o.d. prior to administration of tyloxapol 400\u00a0mg\/kg, i.p.). BChE, SDH, and AR enzyme activities were significantly increased in all tissues in HL\u2010control compared to the control, whereas the activity of other studied enzymes was significantly decreased. Bromelain had a regulatory effect on all tissues and enzyme activities. In conclusion, these results prove that bromelain is a new mediator that decreases hyperlipidemia.<\/jats:p>","DOI":"10.1002\/bab.2517","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T04:25:05Z","timestamp":1695702305000},"page":"17-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Protective effect of bromelain on some metabolic enzyme activities in tyloxapol\u2010induced hyperlipidemic rats"],"prefix":"10.1002","volume":"71","author":[{"given":"Ay\u015fe Nurseli","family":"Sulumer","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Palab\u0131y\u0131k","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science Ataturk University  Erzurum 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