{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:34:10Z","timestamp":1747146850978,"version":"3.40.5"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biotech and App Biochem"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The current research article has investigated the synthesis and characterization of novel iron nanoparticles (INPs) from neem and betel leaves extract combination using response surface methodology\u2013central composite design and coated with chitosan\u2013curcumin (CCINPs) as a biocompatible and contrast agent for magnetic resonance imaging (MRI). The coating of INPs with chitosan and curcumin (CCINPs) was carried out using a simple, easy, chemical\u2010free ultrasonication method and characteristics were confirmed by UV\u2013visible (Vis) spectrophotometer (UV\u2013Vis), Fourier\u2010transform infrared spectroscopy, X\u2010ray diffraction, scanning electron microscope, atomic force microscopy, and vibrating sample magnetometer. The biocompatibility of the particles was ensured by conducting hemolytic and cell viability assays. The nanoparticle was found to be nonhemolytic (&lt;5%) up to 150\u00a0\u03bcg\/mL for both INPs and CCINPs. The cell viability was stable (peripheral blood mononuclear cells\u2010PBMCs) till 48\u00a0h at 150\u00a0\u03bcg\/mL of INPs and CCINPs. Both the test results produced were found to be biocompatible and additionally, an in vitro MRI study of INPs and CCINPs demonstrated the efficiency of the nanoparticle as a negative contrast agent with enhanced contrast nature in CCINPs. Thus, overall results indicate that the green synthesized chemical\u2010free novel CCINPs could be a potential candidate for a wide range of applications such as MRI, drug delivery, and in magnetic fluid hyperthermia.<\/jats:p>","DOI":"10.1002\/bab.2561","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T08:18:53Z","timestamp":1706775533000},"page":"596-608","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimization and chemical free fabrication of green synthesized iron nanoparticles as potential MRI contrast agent"],"prefix":"10.1002","volume":"71","author":[{"given":"Yuwvaranni","family":"S","sequence":"first","affiliation":[{"name":"St. Joseph's College of Engineering Chennai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Punitha","family":"N","sequence":"additional","affiliation":[{"name":"Department of Physics St. Joseph's College of 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