{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:34:12Z","timestamp":1747146852973,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T00:00:00Z","timestamp":1710633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biotech and App Biochem"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Plasma circulating P\u2010selectin glycoprotein ligand\u20101 (PSGL\u20101) levels and its clinical correlation in patients with epithelial ovarian cancer (EOC) are unknown. The study determined plasma PSGL\u20101 levels in EOC patients and investigated its relationship with clinicopathological factors and prognosis. Plasma PSGL\u20101 levels were measured using ELISA in 69 patients with EOC, 34 patients with benign ovarian cystadenoma, and 36 healthy controls. Subsequently, the relationship between PSGL\u20101 levels and clinicopathological characteristics of patients, as well as the prognosis of EOC patients, was examined. Additionally, the specificity and sensitivity of plasma PSGL\u20101 were assessed through ROC curve analysis. Plasma PSGL\u20101 was upregulated in EOC patients compared with healthy subjects and\/or patients with benign ovarian cystadenoma (<jats:italic>p<\/jats:italic> &lt; 0.01). Elevated levels of PSGL\u20101 in the plasma were positively associated with advanced FIGO stage (<jats:italic>p<\/jats:italic> &lt; 0.001), tumor size (<jats:italic>p<\/jats:italic> = 0.001), tumor metastasis (<jats:italic>p<\/jats:italic> = 0.036), and tumor recurrence (<jats:italic>p<\/jats:italic> = 0.013), while was negatively correlated with residual tumor size (<jats:italic>p<\/jats:italic> &lt; 0.001). Kaplan\u2013Meier survival analysis showed that high plasma PSGL\u20101 levels were associated with progression\u2010free survival (<jats:italic>p<\/jats:italic> = 0.0345). In univariate and multivariate Cox regression analyses, PSGL\u20101 (HR = 1.456, <jats:italic>p<\/jats:italic> = 0.009) was an independent prognostic marker. Plasma PSGL\u20101 levels distinguished EOC patients and healthy individuals (AUC = 0.905), patients at late and early FIGO stages (AUC = 0.886), and metastatic and non\u2010metastatic EOC (AUC = 0.722). The expression of plasma PSGL\u20101 is significantly increased in patients with EOC, serving as a reliable biomarker to differentiate between healthy individuals and those with EOC. Furthermore, PSGL\u20101 in patients is correlated with prognostic indicators, such as advanced FIGO stage, tumor lymph node metastasis, and progression\u2010free survival.<\/jats:p>","DOI":"10.1002\/bab.2572","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T05:28:10Z","timestamp":1710739690000},"page":"733-740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Correlation between plasma PSGL\u20101 and FIGO stage, tumor metastasis, and survival in epithelial ovarian cancer"],"prefix":"10.1002","volume":"71","author":[{"given":"WenHui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gynaecology and Obstetrics the First Affiliated Hospital of Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery IV 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