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The process involves the reduction of iron oxide within the ore to attain the desired hematite phase, crucial for synthesizing H\u2010NPs. To ensure sustainability, we adopted a Green Chemistry approach, utilizing a combination of carbon soot and limestone for the purification process, thereby achieving eco\u2010conscious production. The produced H\u2010NPs were thoroughly characterized using various analytical techniques, such as x\u2010ray fluorescence (XRF), x\u2010ray diffraction (XRD), Fourier transmission infrared spectroscopy (FT\u2010IR), and FESEM\u2010EDX (field emission scanning electron microscopy\u2010energy\u2010dispersive x\u2010ray spectroscopy). XRD analysis confirmed the crystalline rhombohedral hexagonal lattice structure, while FT\u2010IR spectra indicated the presence of characteristic Fe\u2013O stretching modes in line with the expected molecular composition. FESEM\u2010EDX imaging unveiled agglomerated particles, ranging in size from 54.6 to 149.9\u00a0nm for iron ore and 22\u00a0nm for H\u2010NPs. These particles were primarily composed of iron (Fe) and oxygen (O). The magnetic properties of the H\u2010NPs were investigated through vibrating sample magnetometer (VSM) studies, highlighting their distinct ferromagnetic behavior. Of particular significance, the H\u2010NPs demonstrated exceptional performance as contrast agents in both x\u2010ray and CT imaging. Even at minimal concentrations, they exhibited remarkable x\u2010ray absorption capabilities. CT scans further validated their exceptional absorptive capacity. These findings emphasize the potential of H\u2010NPs as valuable assets in medical imaging, serving as sustainable tools for enhanced diagnostic applications. The study showcases an eco\u2010conscious approach to harnessing natural resources, paving the way for a greener and more effective utilization of H\u2010NPs in the medical imaging landscape.<\/jats:p>","DOI":"10.1002\/bab.2577","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T09:43:18Z","timestamp":1710495798000},"page":"791-808","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Optimization of hematite nanoparticles from natural ore as novel imaging agents: A Green Chemistry approach"],"prefix":"10.1002","volume":"71","author":[{"given":"Albert","family":"Asha","sequence":"first","affiliation":[{"name":"Department of Physics St. Joseph's Institute of Technology  Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munusamy","family":"Chamundeeswari","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, St. Joseph's College of Engineering Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rayappan Mary Nancy","family":"Flora","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Arunai Engineering College  Tiruvannamalai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuppusamy Ravichandran","family":"Preethy","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, St. Joseph's College of Engineering Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1088\/1468-6996\/16\/2\/023501"},{"key":"e_1_2_8_3_1","volume-title":"Molecular sciences and chemical engineering","author":"Voloshina E","year":"2017"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2021.162154"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-022-05577-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41893-018-0046-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.1c05323"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c02491"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c00883"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.72127"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2007.01785.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.onano.2023.100146"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.2107.09602"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","unstructured":"SnowsillTM YangH GriffinED LongHL Varley\u2010CampbellJ CoelhoH et\u00a0al.Low\u2010dose computed tomography for lung cancer screening in high risk populations: a systematic review and economic evaluation.Southampton UK:NIHR Journals Library;2018.","DOI":"10.3310\/hta22690"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202007305"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","unstructured":"JalilZ RahwantoA MulanaF HandokoE.Synthesis of nano\u2010hematite (Fe2O3) extracted from natural iron ore prepared by mechanical alloying method. 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